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GHRP-2

CAS No.158861-67-7
Chemical Name:GHRP-2
CBNumber:CB1104514
Molecular Formula:C45H55N9O6
Formula Weight:817.97
MOL File:158861-67-7.mol

GHRP-2 Property

Melting point 149 - 151°C
Boiling point 1265.3±65.0 °C(Predicted)
Density 1.270±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO (Slightly, Sonicated), Water (Slightly)
pka 13.40±0.46(Predicted)
form lyophilized powder
color white to beige
Stability Hygroscopic
InChIKey HRNLPPBUBKMZMT-RDRUQFPZSA-N
SMILES C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(=O)[C@@H](C)N
CAS DataBase Reference 158861-67-7(CAS DataBase Reference)
FDA UNII E6S6E1F19M
UNSPSC Code 12352200
NACRES NA.77

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

GHRP-2 Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: SML2056
Product name : Pralmorelin trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 1MG
Price: ₹14776.13
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: SML2056
Product name : Pralmorelin trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: ₹59440.08
Updated: 2022/06/14
Buy: Buy

GHRP-2 Chemical Properties,Usage,Production

Description Pralmorelin (also known as KP-102, GPA-748, GHRP-2, and Growth Hormone Releasing Peptide-2) is a potent GH secretagogue in development as a diagnostic agent for growth hormone deficiency and for the treatment of pituitary disorders and GH deficiency. It acts as signal molecules that are involved in the control of cell growth and differentiation.
Uses Growth hormone releasing factor. Pralmorelin is a growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release.
Definition ChEBI: Pralmorelin is an oligopeptide.
benefits Regulation of blood pressure, increased strength and healing, reduced injury, increased cell rejuvenation, increase in lean muscle mass and stronger bones.
Biochem/physiol Actions Pralmorelin, also known as Growth hormone-releasing peptide 2 or GHRP-2, is an orally-active, synthetic peptide analogue of met-enkephalin that acts as a ghrelin/growth hormone secretagogue receptor (GHSR) agonist to selectively stimulate the ghrelin receptor and cause growth hormone release. Pralmorelin (GHRP-2) has been used clinically for the assessment of growth hormone deficiency (GHD), It has also been shown to have anti-inflammatory activity.
Mechanism of action GHRP-2 is an agonist of ghrelin, a gut peptide and also known as “the hunger hormone”, which binds to the growth hormone secretagogue receptor. Pralmorelin works to enhance natural growth hormone production in two ways. First, the GHRP-2 intensifies the natural growth hormone releasing signal, resulting in a substantial secretion of growth hormone. Second, it suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone (GHIH). Somatostatin generates the body to decrease its natural growth hormone production. By restricting the activity of somatostatin, GHRP-2 can improve growth hormone creation, resulting in increased natural growth hormone levels. GHRP-2 also activates ghrelin, a peptide hormone produced in the gastrointestinal system, which has strong effects on growth hormone production and appetite.
Side effects No side effects or toxicities were observed. Thus, GHRP-2 is well tolerated and can stimulate GH secretion. Formulations or routes of administration that allow for a longer duration of action will likely be needed to use GHRP-2 in therapy[1].
References [1] V Mericq. “Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children.” Journal of Clinical Endocrinology & Metabolism 83 7 (1998): 2355–60.