ChemicalBook > CAS DataBase List > 1-(1-NAPHTHYL)-2-THIOUREA

1-(1-NAPHTHYL)-2-THIOUREA

1-(1-NAPHTHYL)-2-THIOUREA Structure
1-(1-NAPHTHYL)-2-THIOUREA
  • CAS No.86-88-4
  • Chemical Name:1-(1-NAPHTHYL)-2-THIOUREA
  • CBNumber:CB5308200
  • Molecular Formula:C11H10N2S
  • Formula Weight:202.28
  • MOL File:86-88-4.mol
1-(1-NAPHTHYL)-2-THIOUREA Property
  • Melting point 193 °C
  • Boiling point 377.6±25.0 °C(Predicted)
  • Density 1.333
  • refractive index 1.5500 (estimate)
  • storage temp. Poison room
  • solubility 4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983)
  • pka 13.12±0.70(Predicted)
  • form Crystals or Crystalline Powder
  • color Grayish to beige-brown
  • Odor bitter taste
  • Water Solubility 600 mg/L at 20 °C (quoted, Windholz et al., 1983)
  • Merck 14,722
  • BRN 778118
  • Exposure limits NIOSH REL: TWA 0.3 mg/m3, IDLH 100 mg/m3; OSHA PEL: TWA 0.3 mg/m3
  • CAS DataBase Reference 86-88-4(CAS DataBase Reference)
  • EWG's Food Scores 2-3
  • FDA UNII UKY0H6XJ4J
  • IARC 3 (Vol. 30, Sup 7) 1987
  • EPA Substance Registry System .alpha.-Naphthylthiourea (86-88-4)
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :T+
  • Risk Statements  :28-40
  • Safety Statements  :28-36/37-45-25-23
  • RIDADR  :1651
  • OEB :C
  • OEL :TWA: 0.3 mg/m3
  • WGK Germany  :2
  • RTECS  :YT9275000
  • TSCA  :Yes
  • HazardClass  :6.1
  • PackingGroup  :I
  • HS Code  :29309090
  • Hazardous Substances Data :86-88-4(Hazardous Substances Data)
  • Toxicity :Acute oral LD50 for Norwegian rats 6–8 mg/kg (Hartley and Kidd, 1987).
  • IDLA :100 mg/m3
  • NFPA 704:
    1
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300-H351
  • Precautionary statements P201-P202-P264-P270-P280-P301+P310
1-(1-NAPHTHYL)-2-THIOUREA Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: 45328
  • Product name : ANTU
  • Purity: PESTANAL?, analytical standard
  • Packaging: 250MG
  • Price: ₹5098.58
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0071
  • Product name : 1-(1-Naphthyl)-2-thiourea
  • Purity: 
  • Packaging: 5G
  • Price: ₹3400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A19024-30
  • Product name : N-(1-Naphthyl)thiourea, 97%
  • Purity: 
  • Packaging: 250g
  • Price: ₹48682
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0071
  • Product name : 1-(1-Naphthyl)-2-thiourea
  • Purity: 
  • Packaging: 25G
  • Price: ₹11300
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A19024-18
  • Product name : N-(1-Naphthyl)thiourea, 97%
  • Purity: 
  • Packaging: 50g
  • Price: ₹12219
  • Updated: 2022/05/26
  • Buy: Buy

1-(1-NAPHTHYL)-2-THIOUREA Chemical Properties,Usage,Production

  • Description a-Naphthylthiourea (ANTU; also called DIRAX) is toxic by inhalation, ingestion, or skin contact. Due to its very narrow spectrum of activity, production was discontinued a long time ago. Exposure to ANTU causes pulmonary edema; therefore, it is often used as an experimental pneumotoxin. ANTU is a graycolored, prism-shaped, odorless powder with a bitter taste. It has a molecular weight of 202.28 and melting point of 200 ℃ and does not ignite readily. However, on interaction with potential oxidizing agents, it may cause fire and explosions, which can lead to hazardous decomposition products such as sulfur dioxide, nitrogen dioxide, and carbon monoxide. The structure of ANTU contains the naphthalene chromophore, which absorbs UV light at ～311 nm. This suggests that ANTU can undergo photolysis.
  • Chemical Properties ANTU is a noncombustible, white crystalline solid or gray powder. Odorless.
  • Chemical Properties Alpha-naphthylthiourea (α-naphthalene thiourea) is a pure white or beige-brown solid/ blue-gray powder. It is hard to dissolve in water, acid, and general organic solvents, but dissolves in boiling ethanol and alkaline solution. On decomposition, ANTU releases carbon monoxide, toxic and irritating fumes and gases, and carbon dioxide. It is a rodenticide and a poison bait to lure rodents.
  • Chemical Properties greyish to beige-brown crystals or cryst. powder
  • Physical properties Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.
  • Uses ANTU an organosulfur is a derivative of thiourea. It is a singledose rodenticide that is specifically used against Norway rats as a bait. However, it is futile against all other species of rodents. Because of its tendency to cause resistance and specificity only toward Norway rodents, this poison rapidly lost popularity and is no longer manufactured in the United States.
  • Uses Rodenticide. Specific control for the adult Norway rat; less toxic to other rat species.
  • Definition ChEBI: ANTU is a member of naphthalenes.
  • General Description White crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.
  • Air & Water Reactions Slightly soluble in water.
  • Reactivity Profile 1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .
  • Hazard Toxic by ingestion
  • Health Hazard α-Naphthalene thiourea, a rodenticide, is very toxic and is fatal if swallowed. Exposures to ANTU cause poisoning with symptoms that include, but are not limited to, headache, weakness, dizziness, shortness of breath, cyanosis, blood abnormalities, methemoglobinemia, irritation of the digestive tract, liver and kidney damage, cardiac and CNS disturbances, convulsions, tachycardia, dyspnea, vertigo, tinnitus, weakness, disorientation, lethargy, drowsiness, and fi nally coma and death. The target organs include the blood, kidneys, CNS, liver, lungs, cardiovascular system, and blood-forming organs.
  • Health Hazard Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.
  • Fire Hazard Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.
  • Safety Profile Poison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx.
  • Potential Exposure ANTU or its formulations are used as a rodenticide.
  • First aid If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24°48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a corticosteroid spray.
  • Carcinogenicity ANTU was not carcinogenic in rodent feeding studies.4 Cases of bladder tumors among rat catchers exposed to ANTU have been attributed to b-naphthylamine, a manufacturing impurity of ANTU. In bacterial assays ANTU induced mutations.
  • Environmental Fate Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
    Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Lewis, 1990)
  • storage α-Naphthalene thiourea should be kept stored in a tightly closed container in a locked poison room, in a cool, dry, well-ventilated area away from incompatible substances.
  • Shipping UN1651 Naphthylthiourea, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
  • Purification Methods Crystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]
  • Toxicity evaluation ANTU toxicity in the rat is thought to depend on metabolic activation via the hepatic and lung microsomal enzymes. Two important metabolites are formed: ANU and atomic sulfur. ANTU pulmonary toxicity may result, in part, from covalent binding of sulfur or a metabolite containing carbonyl carbon of ANTU to macromolecules of liver and lung microsomes. The covalent binding of atomic sulfur released in the cytochrome P450 monooxygenase-catalyzed metabolism of thiono-sulfur compounds is responsible for monooxygenase activity being inhibited. Damage to liver and possibly lung edema and neoplasia result from the covalent binding of the electrophilic S-oxides, S-dioxides or carbene derivatives of these S-oxides and S-dioxides to tissue macromolecules.
    However, it is not known if these metabolites are seen in humans. ANTU is believed to act on certain enzyme systems involving the sulfhydryl group similar to other sulfhydryl inhibitors, such as alloxan, iodoacetamide, and oxophenarsine, which cause pulmonary edema. Hence the mechanism of action of causing pulmonary edema from the toxic effects of these sulfhydryl inhibitors and ANTU is assumed to be similar. Additionally, ANTU-induced lung damage has been linked to the formation of oxygen free radicals produced via the cyclooxygenase pathway. Following exposure to ANTU, there are a number of biochemical events, such as alteration in carbohydrate metabolism, adrenal stimulation, and interaction of the chemical with sulfhydryl groups, but none of these appear to bear any relationship to the observed signs of toxicity.
  • Incompatibilities Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, silver nitrate.
  • Waste Disposal Incinerate in a furnace equipped with an alkaline scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
  • Precautions Workers should use/handle α-naphthalene thiourea with adequate ventilation. During use, dust generation and accumulation should be minimum, and avoid contact with the eyes, skin, and clothing.
1-(1-NAPHTHYL)-2-THIOUREA Preparation Products And Raw materials
Raw materials
Preparation Products
1-(1-NAPHTHYL)-2-THIOUREA Suppliers
Global(108)Suppliers
  • Supplier： ORGANICA Feinchemie GmbH
  • Tel：+49 3494636389
  • Email：info@organica.de
  • Country：Germany
  • ProdList：598
  • Advantage：65
1-(1-NAPHTHYL)-2-THIOUREA Spectrum
86-88-4, 1-(1-NAPHTHYL)-2-THIOUREARelated Search:
  • Sulphur Derivatives
  • 分析标准品
  • 杀鼠剂
  • 农药
  • C11H10N2S
  • 86-88-47
  • 乙腈中安妥溶液
  • 甲醇中安妥
  • 安妥检测标准品
  • ANTU标准品
  • 1-萘基硫脲,97%
  • 1-萘基硫脲,95%
  • 1-萘基硫脲
  • α-萘基硫脲
  • 安妥
  • 1-(1-萘基)-2-硫脲
  • 2-萘基硫脲
  • N-(1-萘基)硫脲
  • 1-萘基-2-硫脲
  • 1-苦基硫脲
  • α-萘硫脲
  • 86-88-4
  • Antu in Methanol
  • 2-Propen-1-one,1-[(2R,5R)-2-(hydroxymethyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-
  • Bedaquiline Impurity 113
  • 1-(1-phthyl)-2-thiourea
  • Thiourea, N-1-naphthalenyl-
  • 1-(1-NAPHTHYL)-2-THIOUREA USP/EP/BP
  • U 5227
  • Smeesana
  • rcrawastenumberp072
  • Rcra waste number P072
  • Rat-Tu
  • Rattrack
  • Naphtox
  • N-1-Naphthylthiourea
  • N-(1-Naphthyl)-2-thiourea
  • krysidpi
  • Krysid pi
  • Krysid
  • Kripid
  • killkantz
  • Kill kantz
  • Dirax
  • chemical109
  • Chemical 109
  • Bantu
  • Anturat
  • 1-(1-Naphthyl)-2-thiourea,97%
  • Rattract
  • Auturact
  • Antural
  • NSC 3287
  • N-(1-Naphthy)thiourea
  • antu (ISO) 1-(1-naphthyl)-2-thiourea
  • 1-Naphthylthiourea,95%
  • Thiourea,1-naphthalenyl-
  • 1-naftylthioureum (dutch)

Home

My