Pepstatin (Pepstatin A) has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route[1].
Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats[1].
| Animal Model: | Pylorus ligated male Wistar rats[1] |
| Dosage: | 0.5, 1, 10 and 50 mg/kg |
| Administration: | Oral administration, 15 minutes after pyloric ligation |
| Result: | Effectively prevented stomach ulceration. |
