Chemical Properties
Colorless solid
Definition
ChEBI: N-acetyl-leucine is a leucine derivative and a N-acetyl-amino acid.
World Health Organization (WHO)
The products were indicated for the treatment of vertigo and had
been authorized for marketing under the "grandfather" clause, which waives full
registration requirements for products marketed before 1963.
Synthesis
Acetylleucine is synthesized from L-leucine via N-acylation with acetic anhydride in aqueous sodium hydroxide, followed by catalytic thermal racemization and purification through alkaline redissolution and acidification[1].
in vivo
Acetylleucine (60 mg/kg, i.v., on days 1, 2 and 3 after unilateral labyrinthectomy (UL)) accelerates compensation of postural symptoms but not of nystagmus or head roll tilt after UL in rats[3].
References
[1] Mai Van Phong, Pham Nguyen Vu, Vu Duc Thanh. Optimization and Process Scale-up for the Synthesis of Pharmaceutical-Grade N-Acetyl-DL-Leucine from L-Leucine.
