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N-Acetyl-L-leucine

CAS No.1188-21-2
Chemical Name:N-Acetyl-L-leucine
CBNumber:CB9852903
Molecular Formula:C8H15NO3
Formula Weight:173.21
MOL File:1188-21-2.mol

N-Acetyl-L-leucine Property

Melting point 187-190 °C(lit.)
alpha -24.5 º (c=4, MeOH)
Boiling point 303.86°C (rough estimate)
Density 1.1599 (rough estimate)
refractive index -22 ° (C=5, EtOH)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
form Crystalline Powder
pka 3.67±0.10(Predicted)
color White
optical activity [α]25/D 23±3°, c = 2 in ethanol
Water Solubility 0.81 g/100 mL (20 ºC)
BRN 1724849
CAS DataBase Reference 1188-21-2(CAS DataBase Reference)
FDA UNII E915HL7K2O
NIST Chemistry Reference L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System L-Leucine, N-acetyl- (1188-21-2)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :24/25-36-26
WGK Germany :3
TSCA :Yes
HazardClass :IRRITANT
HS Code :29241900

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319-H315-H335
Precautionary statements P271-P261-P280

N-Acetyl-L-leucine Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: 441511
Product name : N-Acetyl-L-leucine
Purity: ReagentPlus?, 99%
Packaging: 25G
Price: ₹9861.58
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0098
Product name : N-Acetyl-L-leucine
Purity:
Packaging: 5G
Price: ₹2300
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0098
Product name : N-Acetyl-L-leucine
Purity:
Packaging: 25G
Price: ₹6200
Updated: 2022/05/26
Buy: Buy

Brand: SRL
Product number: 76097
Product name : N-Acetyl-L-Leucine extrapure, 99%
Purity:
Packaging: 5Gms
Price: ₹1030
Updated: 2022/05/26
Buy: Buy

Brand: SRL
Product number: 76097
Product name : N-Acetyl-L-Leucine extrapure, 99%
Purity:
Packaging: 25Gms
Price: ₹4260
Updated: 2022/05/26
Buy: Buy

N-Acetyl-L-leucine Chemical Properties,Usage,Production

Chemical Properties White crystalline powder
Uses N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.
Definition ChEBI: The N-acetyl derivative of L-leucine.
reaction suitability reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats^[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices^[4].

Animal Model:	Male Sprague-Dawley rats (mean 400±20 g, age 3 months) after chemical UL^[3]
Dosage:	60 mg/kg
Administration:	i.v., 15 days
Result:	Significantly decreased the postural imbalance scores on 7 day and accelerated the course of postural compensation by about 6 days in rats.

Animal Model:	C57/BL6 mice^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 1-28 days
Result:	Did not afect food intake and body weight in mice.

Animal Model:	N-Acetyl-L-leucine-treated TBI mouse cortices^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 28 days
Result:	Prevented cortical cell death which peaks at early time points (day 1) afer TBI in N-Acetyl-L-leucine-treated TBI mouse cortices.