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H-His(Trt)-OH

H-His(Trt)-OH Structure
H-His(Trt)-OH
  • CAS No.35146-32-8
  • Chemical Name:H-His(Trt)-OH
  • CBNumber:CB9185713
  • Molecular Formula:C25H23N3O2
  • Formula Weight:397.47
  • MOL File:35146-32-8.mol
H-His(Trt)-OH Property
  • Melting point 210℃
  • Boiling point 584.8±50.0 °C(Predicted)
  • Density 1.19±0.1 g/cm3(Predicted)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • pka 1.78±0.10(Predicted)
  • form Solid
  • color White to off-white
  • InChI InChI=1S/C25H23N3O2/c26-23(24(29)30)16-22-17-28(18-27-22)25(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,23H,16,26H2,(H,29,30)/t23-/m0/s1
  • InChIKey BSZQZNOAYQCQFZ-QHCPKHFHSA-N
  • SMILES C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)N
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

H-His(Trt)-OH Chemical Properties,Usage,Production

  • Chemical Properties White powder
  • Uses 1-(Triphenylmethyl)-L-histidine is a reactant in the synthesis of falcitidin acyl tetrapeptides as antimalarial agent.
  • Preparation The amino acid N(im)-trityl-D-histidine was dissolved in dichloromethane, followed by the addition of triethylamine and trimethylsilyl chloride (3.5 equivalents). After 2 hours of gentle reflux, the mixture was ready to be used for in situ coupling to the anhydride of the carboxylic acid. Thus, isovaleric acid was separately dissolved in THF and maintained at -20 ℃ using an ice-salt bath. N-methyl morpholine (1.2 equivalents) was added, followed by the addition of ethyl chloroformate (1.0 equivalent). After 15-20 minutes at -20 ℃, the bis-TMS amino acid reaction mixture was added directly to the anhydride solution and left stirring at room temperature overnight. After 8 hours, the reaction mixture was concentrated in vacuo. Finally, H-His(Trt)-OH was obtained after purification.H-HIS(TRT)-OH
  • Definition H-His(Trt)-OH, also known as 1-(Triphenylmethyl)-L-histidine, is a histidine derivative. It can be obtained by removing fmoc group protection from Fmoc-His(Trt)-OH. L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system.
H-His(Trt)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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H-His(Trt)-OH Spectrum
35146-32-8, H-His(Trt)-OHRelated Search:
  • Peptide Synthesis
  • Histidine
  • Amino Acid Derivatives
  • Amino Acids and Derivatives
  • Histidine [His, H]
  • 抑制剂
  • 生化试剂
  • 化学试剂
  • 索玛鲁肽
  • 索玛鲁肽接头
  • 氨基酸
  • 天然氨基酸极其衍生物
  • 保护氨基酸
  • Amino Acid Derivatives
  • Specialty Synthesis
  • Peptide Synthesis
  • Histidine
  • C25H23N3O2
  • 化合物 H-HIS(TRT)-OH
  • 1-三苯甲基-L-组氨酸,98%
  • (2S)-2-氨基-3-(1-三苯代甲基咪唑-4-基)丙酸
  • N-IM-三苯甲基-组氨酸
  • L-组氨酸(三苯甲基)
  • N(IM)-(三苯甲基)-L-组氨酸
  • N'-(三苯甲基)-L-组氨酸
  • 1-三苯甲基-L-组氨酸
  • 35146-32-8
  • 1-Trityl-L-histidine, 98%
  • H-HIS(TRT)-OH USP/EP/BP
  • (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicaci
  • L-Histidine, 1-(triphenylmethyl)-
  • (S)-2-Amino-3-(1-trityl-1H-imidazol-4-yl)propanoicacid
  • (2S)-2-ammonio-3-(1-trityl-1H-imidazol-4-yl)propanoate
  • L-His(Trt)
  • (2S)-2-amino-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid
  • (2S)-2-amino-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
  • (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicacid
  • H-His(tau-Trt)-OH
  • N<T/(IM)>-TRITYL-L-HISTIDINE
  • His(Trt)
  • N-TAU-TRITYL-L-HISTIDINE
  • N-IM-TRITYL-L-HISTIDINE
  • N-IM-TRITYL-HISTIDINE
  • RARECHEM AL BE 1480
  • H-HIS(TRT)-OH
  • H-HIS(T-TRT)-OH
  • H-HIS(1-TRT)-OH
  • HISTIDINE(1-TRT)-OH
  • H-L-HIS(TRT)-OH
  • 1-Trityl-L-histidine, 98%
  • Nim-Trityl-histidine≥ 98% (HPLC)
  • L-His(Trt)-OH
  • L-His(Trt)·H2O
  • 1-(Triphenylmethyl)-L-histidine
  • N-τ-Trityl-L-histidine

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