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Fmoc-Asn(Trt)-OH

CAS No.132388-59-1
Chemical Name:Fmoc-Asn(Trt)-OH
CBNumber:CB4331632
Molecular Formula:C38H32N2O5
Formula Weight:596.67
MOL File:132388-59-1.mol

Fmoc-Asn(Trt)-OH Property

Melting point 201-204 °C(lit.)
alpha -16 º (c=1, MeOH)
Boiling point 858.1±65.0 °C(Predicted)
Density 1.271±0.06 g/cm3(Predicted)
refractive index -19 ° (C=1, DMF)
storage temp. 2-8°C
solubility <0.00005g/l
pka 3.79±0.10(Predicted)
form powder to crystal
color White to Almost white
optical activity [α]20/D 15.0±1°, c = 1% in methanol
Water Solubility <0.00005g/L
BRN 4343823
InChIKey KJYAFJQCGPUXJY-UUWRZZSWSA-N
SMILES C(O)(=O)[C@H](CC(N)=O)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference 132388-59-1(CAS DataBase Reference)
FDA UNII 5R94765WYL
UNSPSC Code 12352209
NACRES NA.26

Safety

Risk Statements :53
Safety Statements :24/25-61
RIDADR :UN 3077 9 / PGIII
WGK Germany :2
F :3-10
HS Code :2924 29 70
HazardClass :IRRITANT
Toxicity :LD50 orally in Rabbit: > 2000 mg/kg

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H411
Precautionary statements P273-P391-P501

Fmoc-Asn(Trt)-OH Price More Price(18)

Brand: Sigma-Aldrich(India)
Product number: 8.52044
Product name : FMOC-Asn(Trt)-OH
Purity: N-α-Fmoc-N-?-trityl-L-asparagine Novabiochem?
Packaging: 25G
Price: ₹5800.01
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.52044
Product name : FMOC-Asn(Trt)-OH
Purity: N-α-Fmoc-N-?-trityl-L-asparagine Novabiochem?
Packaging: 100G
Price: ₹13940
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.52044
Product name : FMOC-Asn(Trt)-OH
Purity: N-α-Fmoc-N-?-trityl-L-asparagine Novabiochem?
Packaging: 250G
Price: ₹29660.01
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 47672
Product name : Fmoc-Asn(Trt)-OH
Purity: ≥97.0%
Packaging: 5G
Price: ₹7155.33
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 47672
Product name : Fmoc-Asn(Trt)-OH
Purity: ≥97.0%
Packaging: 25G
Price: ₹10640.98
Updated: 2022/06/14
Buy: Buy

Fmoc-Asn(Trt)-OH Chemical Properties,Usage,Production

Description Fmoc-Asn(Trt)-OH prevents the possibility of the amide side chain from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Asn(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Asn-OH is only somewhat soluble in NMP or DMF. The trityl group is removed with TFA. This reaction is usually complete within 1 hour at room temperature, but is slower when the Asn(Trt) residue in at the N-terminal of the peptide. In these cases, the deprotection reaction should be extended to 2 hours.
Chemical Properties white crystal powde
Uses Fmoc-Asn(Trt)-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.
Preparation Synthesis of Fmoc-Asn(Trt)-OH:
Step 1: Crystallization to form N'-Trityl-L-asparagine crystals.
Step 2: Centrifugation to extract N'-Trityl-L-asparagine crystals.
Step 3: Washing to remove residual starting materials in the synthesis.
Step 4: Extraction to obtain N-Acetyl-L-asparagine.
Step 5: Centrifugation to extract N'-Trityl-L-asparagine.
Step 6: Drying to obtain the final product.
This synthesis method effectively removes residual synthetic materials such as trifluoroacetic acid, maleic anhydride, and epichlorohydrin, which are similar in chemical properties to N-Acetyl-L-asparagine, from the product during the production process. The purification method is simple and the product obtained has high purity.
reaction suitability reaction type: Fmoc solid-phase peptide synthesis