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TEMAZEPAM

TEMAZEPAM Structure
TEMAZEPAM
  • CAS No.846-50-4
  • Chemical Name:TEMAZEPAM
  • CBNumber:CB9185627
  • Molecular Formula:C16H13ClN2O2
  • Formula Weight:300.74
  • MOL File:846-50-4.mol
TEMAZEPAM Property
  • Melting point 119-121°C
  • Boiling point 211°C (rough estimate)
  • Density 1.2682 (rough estimate)
  • refractive index 1.5200 (estimate)
  • Flash point 11 °C
  • storage temp. 2-8°C
  • solubility Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
  • pka pKa 1.6 (Uncertain)
  • BCS Class 2
  • CAS DataBase Reference 846-50-4(CAS DataBase Reference)
  • EWG's Food Scores 1
  • FDA UNII CHB1QD2QSS
  • Proposition 65 List Temazepam
  • ATC code N05CD07
  • IARC 3 (Vol. 66) 1996
  • EPA Substance Registry System Temazepam (846-50-4)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501

TEMAZEPAM Chemical Properties,Usage,Production

  • Chemical Properties Crystalline Solid
  • Originator Levanxol,Carlo Erba,Italy,1970
  • Uses Pharmacologically active labelled metabolite of Diazepam. Controlled substance (depressant). Sedative, hypnotic
  • Uses Pharmacologically active metabolite of Diazepam. Controlled substance (depressant). Sedative, hypnotic
  • Uses Temazepam, is pharmacologically active metabolite of Diazepam (D416855). It is Sedative, and hypnotic. Controlled substance (depressant).
  • Definition ChEBI: Temazepam is a benzodiazepine.
  • Manufacturing Process According to British Patent 1,022,645 3.4 g of 3-acetoxy-7-chloro-1-methyl-5- phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one suspended in 80 ml alcohol was treated with 6 ml of 4 N NaOH. After complete solution had taken place, a solid precipitated; this solid was redissolved by the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals which were recrystallized from alcohol to yield 7-chloro-3-hydroxy-5-phenyl-1- methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, MP 119° to 121°C.
  • brand name Restoril (Tyco); Temaz (Quantum Pharmics).
  • Therapeutic Function Tranquilizer
  • World Health Organization (WHO) Temazepam is a widely used benzodiazepine derivative. As with other drugs in this class, cases of misuse and drug dependence are known.
  • General Description Temazepam, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl -2H-1,4-benzodiazepine-2-one(Restoril), also occurs as a minor metabolite of diazepam.It can be visualized as N-methyl oxazepam, and indeed, asmall amount of N-demethylation occurs slowly. However,metabolism proceeds mainly through glucuronidationof the 3-hydroxyl group, thus, it is intermediate acting andmarketed as a hypnotic said to have little or no residualeffect.
  • Clinical Use Benzodiazepine:
    Insomnia (short-term use)
    Pre-med anxiolytic prior to minor procedures
  • Drug interactions Potentially hazardous interactions with other drugs
    Antibacterials: metabolism possibly increased by rifampicin.
    Antipsychotics: increased sedative effects; risk of serious adverse effects in combination with clozapine.
    Antivirals: concentration possibly increased by ritonavir.
    Disulfiram: metabolism of temazepam inhibited (increased toxicity).
    Sodium oxybate: enhanced effects of sodium oxybate - avoid.
  • Metabolism Temazepam is metabolised mainly in the liver. It is excreted mainly in the urine in the form of its inactive glucuronide conjugate together with small amounts of the demethylated derivative, oxazepam, also in conjugated form.
TEMAZEPAM Preparation Products And Raw materials
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TEMAZEPAM Spectrum
846-50-4, TEMAZEPAMRelated Search:
  • pharmaceutical intermediate
  • Isotope Labeled Compounds
  • Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
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  • Heterocycles
  • 其他兽药标准品
  • Analytical Chromatography Product Catalog
  • Alphabetic
  • Analytical Standards
  • TA - TE
  • C1513CH10D3ClN2O2
  • 羟基安定(RING-[A]-13C6,98%)50UG/ML 溶于甲醇,CP95%+
  • 替马西泮溶液,100PPM
  • 羟基安定 溶液
  • TEMAZEPAM[受控]
  • 替马西泮
  • 甲羟安定
  • 羟基安定
  • 甲醇(替马西泮)
  • 846-50-4
  • Temazepam CIV (1643408)
  • Temazepam D8 HClQ: What is Temazepam D8 HCl Q: What is the CAS Number of Temazepam D8 HCl
  • TEMAZEPAM USP/EP/BP
  • (3RS)-7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro- 2H-1,4-benzodiazepin-2-one
  • Temazepam (CRM)
  • Temazepam Solution, 100ppm
  • TEMAZEPAM
  • 3-Hydroxydiazepam
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-
  • 1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
  • TeMazepaM (100 μg/ML in Methanol)
  • temazepam--dea schedule iv item
  • temazepam methanol solution
  • Methanol(test Temazepam,1.0mg/mL)
  • Temazepam [Controlled Substance]
  • Temazepam CIV (200 mg)
  • 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
  • Hydroxydrazepam
  • Temazepam solution
  • Temazepam-13C,d3
  • Restoril-13C,d3
  • Remestan-13C,d3
  • Perdorm-13C,d3
  • Oxydiazepam-13C,d3
  • Normison-13C,d3
  • N-Methyloxazepam-13C,d3
  • ER 115-13C,d3
  • 7-Chloro-1,3-dihydro-3-hydroxy-1-(methyl-13C,d3)-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 3-Hydroxydiazepam-13C,d3
  • NSC 246303
  • TEMAZEPAM,1.0MG/MLINMETHANOL
  • AURORA KA-7273
  • Perdorm
  • Oxydiazepam
  • Normison

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