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- CAS:
- 846-50-4
- MF:
- C16H13ClN2O2
- MW:
- 300.74
Properties
- Melting point::
- 119-121°C
- Boiling point::
- 211°C (rough estimate)
- Density :
- 1.2682 (rough estimate)
- refractive index :
- 1.5200 (estimate)
- Flash point::
- 11 °C
- storage temp. :
- 2-8°C
- solubility :
- Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
- pka:
- pKa 1.6 (Uncertain)
- BCS Class:
- 2
SecurityInformation
- Symbol(GHS) :
-
GHS07
- Signal word :
- Warning
- Hazard statements :
- H302
- Precautionary statements :
- P264-P270-P301+P312-P330-P501
- Hazard Codes :
- Xn,T,F
- Risk Statements :
- 22-39/23/24/25-23/24/25-11
- Safety Statements :
- 16-36/37-45-7
- RIDADR :
- UN 1230 3/PG 2
- WGK Germany :
- 3
- RTECS :
- DF1225000
- HS Code :
- 2933910000
- Toxicity:
- LD50 oral in rat: 2gm/kg
- Use:
- Temazepam, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl -2H-1,4-benzodiazepine-2-one(Restoril), also occurs as a minor metabolite of diazepam.It can be visualized as N-methyl oxazepam, and indeed, asmall amount of N-demethylation occurs slowly. However,metabolism proceeds mainly through glucuronidationof the 3-hydroxyl group, thus, it is intermediate acting andmarketed as a hypnotic said to have little or no residualeffect.
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