Description
The isomer of isoliensinine (q.v.), this alkaloid is present in the embryo of the
seeds of Nelumbo nucifera Gaertn.
Chemical Properties
Soluble in chloroform, methanol and ethanol, insoluble in ether and water. Derived from the germ of mature seeds of lotus (Nelumbo nucifera Gaevth.), Water lily family.
Uses
Liensinine is a bisbenzylisoquinoline alkaloid with inhibitory properties towards the activation of microglial cells. In testing with rats, iensinine decreased epileptic discharges were observed on electrocorticograms.
Definition
ChEBI: Liensinine is a member of isoquinolines.
in vivo
Liensinine (oral gavage, 100 or 200 mg/kg, daily, 10 weeks) can effectively treat periodontitis, similar to metronidazole-type drugs, and has a certain dose-dependent[2].
| Animal Model: | KM mice[2] |
| Dosage: | 100 mg/kg, 200 mg/kg |
| Administration: | oral gavage, daily, 10 weeks |
| Result: | Reduced the gingival index and increased the SOD levels, the CAT, GSH-Px levels and decreased the NO, MDA, and ET levels compared to the control group. |
| Animal Model: | Institute of Cancer Research (ICR) mice (male, 20-22 g)[3] |
| Dosage: | |
| Administration: | 5 mg/kg by oral administration; 1 mg/kg by intravenous administration |
| Result: | The pharmacokinetic parameters of Liensinine in mice
| Parameters | po (5 mg/kg) | iv (1 mg/kg) | |
| AUC(0-t) (ng/mL*h) | 18.8 ± 2.7 | 211.2 ± 54.9 | |
| AUC(0-∞) (ng/mL*h) | 19.1 ± 2.8 | 227.9 ± 60.1 | |
| MRT(0-t)( h) | 3.2 ± 0.4 | 2.6 ± 0.5 | |
| MRT(0-∞) (h) | 3.4 ± 0.5 | 3.5 ± 0.9 | |
| t1/2z (h) | 1.9 ± 0.2 | 3.8 ± 0.8 | |
| CLz/F (L/h/kg) | 266.0 ± 41.3 | 4.7 ± 1.2 | |
| Vz/F (L/kg) | 708.5 ± 79.9 | 25.9 ± 11.0 | |
| Cmax (ng/mL) | 5.3 ± 0.2 | 169.5 ± 53.5 |
|
References
Tse-yuan et al., Sci. Sinica., 11, 215 (1962)
Pei-chuanetal., ibid, 11,321 (1962)
