ChemicalBook > CAS DataBase List > Neferine

Neferine

Neferine Structure
Neferine
  • CAS No.2292-16-2
  • Chemical Name:Neferine
  • CBNumber:CB5706015
  • Molecular Formula:C38H44N2O6
  • Formula Weight:624.77
  • MOL File:2292-16-2.mol
Neferine Property
  • Melting point 59-61 °C
  • Boiling point 710.9±60.0 °C(Predicted)
  • Density 1.185±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: >15mg/mL
  • form powder
  • pka 9.28±0.45(Predicted)
  • color white to beige
  • optical activity [α]/D -34 to -44° (c=0 3. CHCl3)
  • InChIKey MIBATSHDJRIUJK-ROJLCIKYSA-N
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • RTECS  :SM9495000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Neferine Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0349
  • Product name : Neferine
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11268.83
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0349
  • Product name : Neferine
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹44739.73
  • Updated: 2022/06/14
  • Buy: Buy

Neferine Chemical Properties,Usage,Production

  • Description A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.
  • Uses Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.
  • Definition ChEBI: Neferine is a member of isoquinolines.
  • Biochem/physiol Actions Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
  • in vivo

    Neferine treatment at both low-dose (60 mg/kg/day by gavage) and high-dose (120 mg/kg/day by gavage) reduces the increment of collagen I, III and TGF-β1 protein expression induced by hyperglycemia[2].

  • IC 50 p65; Autophagy
  • References Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)
Neferine Preparation Products And Raw materials
Raw materials
Preparation Products
Neferine Suppliers
Global(209)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
Neferine Spectrum
2292-16-2, NeferineRelated Search:
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • 生物碱类
  • 抑制剂
  • 高端化学
  • 试剂
  • 化合物
  • 植物单体
  • 20版药典新增
  • 标准品，对照品
  • 标准品 -中药标准品
  • 分析试剂-标准品
  • 标准品-中药标准品
  • 分析试剂标准品
  • 标准品-对照品
  • 中药标准品
  • 植提标准品
  • 对照品
  • 植物提取物
  • 分析标准品
  • 对照品,标准品
  • 标准品
  • 中药对照品
  • 中草药成分
  • 甲基莲心碱,10 MM DMSO 溶液
  • 甲基莲心碱/黄酮
  • 甲基莲心碱荷花碱
  • 标准品对照品】NEFERINE
  • 4-(((S)-6,7-二甲氧基-2-甲基-1,2,3,4-四氢异喹啉-1-基)甲基)-2-(((R)-6-甲氧基-1-(4-甲氧基苄基)-2-甲基-1,2,3,4-四氢异喹啉-7-基)氧基)苯酚
  • 甲基莲心碱对照品,
  • NEFERINE 甲基莲心碱 标准品
  • 荷花碱
  • 甲基莲心碱(标准品)
  • NEFERINE 甲基莲心碱
  • 甲基莲心碱
  • 2292-16-2
  • Neferine, 10 mM in DMSO
  • 4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol
  • Neferine USP/EP/BP
  • 4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol
  • Methylliensinine
  • 4''-O-Methylliensinine
  • NEFERINE
  • Neferin
  • 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
  • 4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol
  • 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol
  • Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-

Home

My