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atrasentan

atrasentan Structure
atrasentan
  • CAS No.173937-91-2
  • Chemical Name:atrasentan
  • CBNumber:CB91320566
  • Molecular Formula:C29H38N2O6
  • Formula Weight:510.62
  • MOL File:173937-91-2.mol
atrasentan Property
  • Melting point 122-124°
  • Boiling point 659.4±55.0 °C(Predicted)
  • Density 1.188±0.06 g/cm3(Predicted)
  • storage temp. -20°C Freezer, Under inert atmosphere
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 3.49±0.60(Predicted)
  • color Off-White
  • NCI Dictionary of Cancer Terms atrasentan
  • FDA UNII V6D7VK2215
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

atrasentan Chemical Properties,Usage,Production

  • Uses Palliative treatment of bone pain due to metastatic prostate cancer and disease progression (endothelin (ETA) receptor antagonist).
  • Uses Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
  • Definition ChEBI: Atrasentan is a member of pyrrolidines.
  • in vivo

    Atrasentan (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats[1]. Aatrasentan (ABT-627, 10 mg/kg, i.p.) as well as Taxotere alone inhibited the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model[2].

atrasentan Preparation Products And Raw materials
Raw materials
Preparation Products
atrasentan Suppliers
Global(87)Suppliers
  • Supplier：
    career henan chemical co
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    InvivoChem
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atrasentan Spectrum
173937-91-2, atrasentanRelated Search:
  • API
  • 抑制剂
  • 黄金产品
  • 医药原料
  • G蛋白偶联受体&G蛋白
  • 阿曲生坦,10 MM DMSO 溶液
  • (2R,3R,4S)-4-(苯并[D][1,3]二氧杂环戊烯-5-基)-1-(2-(二丁基氨基)-2-氧代乙基)-2-(4-甲氧基苯基)吡咯烷-3-羧酸
  • (2R,3R,4S)-4-(苯并[D][1,3]二氧杂环-5-基)-1-(2-(二丁基氨基)-2-氧乙基)-2-(4-甲氧基苯基)吡咯烷-3-羧酸
  • ABT-627; (+)-A 127722; A-147627
  • (2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸
  • 阿曲生坦
  • 173937-91-2
  • Atrasentan, 10 mM in DMSO
  • (2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
  • Atrasentan,Endothelin Receptor,A 147627,ABT627,Inhibitor,inhibit,A147627,ABT 627
  • (2R,3R,4S)-4-(Benzod1,3dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid.HCl
  • 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-, (2R,3R,4S)-
  • Atrasentan [2R,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[[(N,N-dibutylamino)-carboxyl]methyl]pyrrolidine-3-carboxylic acid
  • (+)-A 127722; ABT-627; A 127722; ABT 627
  • Atrasentan (ABT-627)
  • A127722, CID 5310990
  • (2S,3S,4R)-4-(1,3-BENZODIOXOL-5-YL)-1-[2-(DIBUTYLAMINO)-2-OXOETHYL]-2-(4-METHOXYPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID
  • (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
  • A-147627
  • (+)-A 127722
  • (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
  • atrasentan

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