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kaurenoic acid

kaurenoic acid Structure
kaurenoic acid
  • CAS No.6730-83-2
  • Chemical Name:kaurenoic acid
  • CBNumber:CB91316121
  • Molecular Formula:C20H30O2
  • Formula Weight:302.45
  • MOL File:6730-83-2.mol
kaurenoic acid Property
  • Melting point 171-172 °C
  • Boiling point 426.6±34.0 °C(Predicted)
  • Density 1.10±0.1 g/cm3(Predicted)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 10 mg/ml
  • form A solid
  • pka 4.70±0.40(Predicted)
  • color White to off-white
  • FDA UNII D572D9R2TZ
  • UNSPSC Code 41116107
  • NACRES NA.25
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
kaurenoic acid Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SMB00177
  • Product name : Kaurenoic acid
  • Purity: ≥95% (LC/MS-ELSD)
  • Packaging: 1MG
  • Price: ₹44328.38
  • Updated: 2022/06/14
  • Buy: Buy

kaurenoic acid Chemical Properties,Usage,Production

  • Description Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.
  • Uses ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.
  • Definition ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity.
  • in vivo

    Kaurenoic acid (1-10 mg/kg, i.g., single dose) reduces peritonitis and pain induced by lipopolysaccharides (HY-D1056) in mice[2].
    Kaurenoic acid (as a diterpene compound) is the main active ingredient in the root bark extract of A. senegalensis that exhibits anticonvulsant effects in mice[3].

    Animal Model:Mice induced by LPS[2]
    Dosage:1, 3, 10 mg/kg; single dose
    Administration:i.g.
    Result:Inhibited LPS-induced mechanical and thermal hyperalgesia, suppressed MPO activity, regulated the redox state of mouse paws, inhibited the production of pro-inflammatory/pain cytokines (such as TNF-α, IL-1β, and IL-33), and enhanced the production of anti-inflammatory/analgesic cytokine IL-10.
kaurenoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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kaurenoic acid Spectrum
6730-83-2, kaurenoic acidRelated Search:
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  • 对照品-中药对照品
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  • 植物提取物
  • 异贝壳杉烯酸,10 MM DMSO 溶液
  • 异贝壳杉烯酸/HPLC
  • (4R,4AS,6AS,9S,11AR,11BS)-4,11B-二甲基-8-亚甲基十四氢-6A,9-甲基环庚[A]萘-4-羧酸
  • 贝壳衫烯酸标准品
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  • 贝壳杉烯酸/异贝壳杉烯酸
  • 贝壳烯酸
  • 异贝壳衫烯酸
  • 贝壳衫烯酸
  • 异贝壳杉烯酸
  • 贝壳杉烯酸
  • 6730-83-2
  • Kaurenoic acid, 10 mM in DMSO
  • Kaurenoic acid-RM
  • (4R,4aS,6aS,9S,11aR,11bS)-4,11b-Dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
  • Kaur-16-en-18-oic acid, (4α)-
  • kaurenoate
  • (5Β,8α,9Β,10α)-Kaur-16-en-18-oic acid
  • (4R,6aS,9R,11bS)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
  • ent-kaur-16-en-19-oicaci
  • (4R,4aS,6aS,9R,11aR,11bS)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
  • Kauren-19-oic acid
  • Kaur-16-en-18-oic acid,(4a)-
  • NSC 339145
  • ent-Kaur-16-en-19-oic acid
  • ent-Kaur-16(17)-en-19-oic acid
  • Kaurane-16-ene-18-oic acid
  • Cunabic acid
  • (-)-Kaur-16-en-18-oic acid
  • kaurenoic acid

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