FK-3311
- CAS No.116686-15-8
- Chemical Name:FK-3311
- CBNumber:CB91247805
- Molecular Formula:C15H13F2NO4S
- Formula Weight:341.33
- MOL File:116686-15-8.mol
- Boiling point 431.3±55.0 °C(Predicted)
- Density 1.419±0.06 g/cm3(Predicted)
- storage temp. Store at RT
- solubility Soluble in DMSO
- form White solid
- pka 6.82±0.10(Predicted)
- color Light yellow to yellow
- UNSPSC Code 51111800
- NACRES NA.77
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
- Brand: Sigma-Aldrich(India)
- Product number: 236015
- Product name : COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem
- Purity: The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is prim
- Packaging: 5MG
- Price: ₹14260
- Updated: 2022/06/14
- Buy: Buy
FK-3311 Chemical Properties,Usage,Production
- Uses COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID.
- Biological Activity Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E 2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo . Anti-inflammatory.
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in vivo
L-PVR, CO, PaO(2), and WDR were significantly better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly reduced in the FK group compared to the control group. The serum TxB(2) levels were significantly lower in the FK group than in the control group, while 6-keto-PGF(1alpha) levels were not significantly reduced. Two-day survival rate was significantly better in the FK group than in the control group[2].
Survival rate was significantly better and serum GOT levels 30 min after reperfusion were significantly lower in the FK high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control[3]. - IC 50 COX-2
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- N-Acetyl-L-cysteine N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI) M-(4-FLUOROPHENOXY)TOLUENE 3-(4-FLUOROPHENOXY)BENZALDEHYDE Flosulide 1-(4-AMINO-3-METHOXYPHENYL)-1-ETHANONE FK-3311 2-(2-FLUOROPHENOXY)ANILINE (2-PHENOXY)METHYLSULFONYLANILINE 2-(4-FLUOROPHENOXY)ANILINE M-(2-FLUOROPHENOXY)TOLUENE 1-(3-phenoxyphenyl)ethanone
- 药靶配体
- 抑制剂
- 化合物FK 3311,10 MM DMSO 溶液
- FK 3311,环氧合酶2(COX-2)抑制剂
- 化合物FK 3311
- N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
- 116686-15-8
- FK 3311, 10 mM in DMSO
- COX,Cyclooxygenase,Inhibitor,inhibit,FK 3311,FK3311
- Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-
- COX-2 Inhibitor V
- FK-3311; FK3311
- CS-1073
- COX-2 Inhibitor V, FK3311
- N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]-methanesulfonamide FK3311
- N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
- FK-3311