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Flosulide

Flosulide Structure
Flosulide
  • CAS No.80937-31-1
  • Chemical Name:Flosulide
  • CBNumber:CB51178758
  • Molecular Formula:C16H13F2NO4S
  • Formula Weight:353.344
  • MOL File:80937-31-1.mol
Flosulide Property
  • Melting point 156 °C(Solv: ethanol (64-17-5))
  • Boiling point 446.9±55.0 °C(Predicted)
  • Density 1.506±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • pka 6.95±0.20(Predicted)
  • FDA UNII GVR41S4ZHJ
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

Flosulide Chemical Properties,Usage,Production

  • Uses Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
  • in vivo

    In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3].

  • IC 50 COX-2
  • References [1] Turull A, et al. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. Inflammation. 2001 Apr;25(2):119-28. DOI:10.1023/a:1007122706770
    [2] Zimmermann KC, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59(1):198-204. PMID:9892207
    [3] Heise G, et al. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis. Nephron. 1998 Oct;80(2):220-6. DOI:10.1159/000045171
Flosulide Preparation Products And Raw materials
Raw materials
Preparation Products
Flosulide Suppliers
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Flosulide Spectrum
80937-31-1, FlosulideRelated Search:
  • 抑制剂
  • 化合物 FLOSULIDE
  • 化合物 T11296
  • 氟舒胺
  • 80937-31-1
  • Methanesulfonamide, N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]-
  • ZK-38997
  • N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide
  • Flosulide
  • N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide
  • CGP-28328
  • CGP-28238

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