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Lorcainide

Lorcainide Structure
Lorcainide
  • CAS No.59729-31-6
  • Chemical Name:Lorcainide
  • CBNumber:CB8875468
  • Molecular Formula:C22H27ClN2O
  • Formula Weight:370.92
  • MOL File:59729-31-6.mol
Lorcainide Property
  • Melting point 263 °C
  • Boiling point 503.0±50.0 °C(Predicted)
  • Density 1.161±0.06 g/cm3(Predicted)
  • pka 9.48±0.20(Predicted)
  • FDA UNII KGJ2T0N7IQ
  • ATC code C01BC07
Safety
  • Toxicity :LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Lorcainide Chemical Properties,Usage,Production

  • Originator Remivox,Janssen,W. Germany,1980
  • Uses Cardiac depressant (anti-arrhythmic).
  • Definition ChEBI: Lorcainide is a member of acetamides.
  • Manufacturing Process To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane is added and stirring and refluxing is continued for another 19 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2 parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl] benzeneacetamide hydrochloride; melting point 263°C.
  • Therapeutic Function Antiarrhythmic
  • Side effects Side effects include insomnia and gastrointestinal disturbances.
Lorcainide Preparation Products And Raw materials
Raw materials
Preparation Products
Lorcainide Suppliers
Global(14)Suppliers
  • Supplier：
    Sinoway Industrial co., ltd.
  • Tel：0592-5800732;<br/>+8613806035118
  • Email：xie@china-sinoway.com
  • Country：China
  • ProdList：987
  • Advantage：58
  • Supplier： LGM Pharma
  • Tel：1-(800)-881-8210
  • Email：inquiries@lgmpharma.com
  • Country：United States
  • ProdList：2123
  • Advantage：70
  • Supplier： DebyeTec.com Inc.
  • Tel：18086626237<br/>18086626237
  • Email：sales@debyesci.com
  • Country：China
  • ProdList：3008
  • Advantage：56
Lorcainide Spectrum
59729-31-6, LorcainideRelated Search:
  • 药物
  • 心脑血管药物
  • 抗心律失常药
  • C22H27ClN2O
  • N-(4-氯苯基)-N-(1-异丙基哌啶-4-基)苯乙酰胺
  • 氯卡胺
  • 劳卡胺
  • 劳卡尼
  • 哌苯醋胺
  • 洛开酰胺
  • 氯克律
  • 芬尼卡
  • 芬卡胺
  • 59729-31-6
  • Lorcainide USP/EP/BP
  • N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide
  • Lorcamide
  • BenzeneacetaMide,N-(4-chlorophenyl)-N-[1-(1-Methylethyl)-4-piperidinyl]-
  • N-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamide
  • Ro-13。1042
  • R-15889
  • N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
  • Lorivox：Remivox
  • Lopantrol
  • Lorcainide

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