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Pyridoxine hydrochloride

Nutrition supplements

CAS No.58-56-0
Chemical Name:Pyridoxine hydrochloride
CBNumber:CB8853882
Molecular Formula:C8H12ClNO3
Formula Weight:205.64
MOL File:58-56-0.mol

Pyridoxine hydrochloride Property

Melting point 214-215 °C(lit.)
Density 1.2784 (rough estimate)
vapor density 7.1 (vs air)
refractive index 1.5800 (estimate)
Flash point 9℃
storage temp. room temp
solubility H₂O: 0.1 g/mL at 20 °C, clear, colorless
form Crystalline Powder
color White to almost white
PH Range 3.2
biological source synthetic (organic)
Water Solubility 0.1 g/mL (20 ºC)
Sensitive Light Sensitive
Merck 14,7982
BRN 3632435
BCS Class 1
Stability Stable. Protect from air and light.
LogP -1.098 (est)
CAS DataBase Reference 58-56-0(CAS DataBase Reference)
FDA 21 CFR 184.1676; 582.5676; 310.545
Substances Added to Food (formerly EAFUS) PYRIDOXINE HYDROCHLORIDE
SCOGS (Select Committee on GRAS Substances) Pyridoxine hydrochloride
FDA UNII 68Y4CF58BV
NCI Drug Dictionary Hexa-Betalin
EPA Substance Registry System 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride (58-56-0)
UNSPSC Code 41116107
NACRES NA.55

Safety

Hazard Codes :Xi,T,F
Risk Statements :36/37/38-39/23/24/25-23/24/25-11
Safety Statements :26-37/39-45-36/37-16-7-24/25
RIDADR :UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany :2
RTECS :UV1350000
F :8-10
TSCA :Yes
HS Code :29362500
Hazardous Substances Data :58-56-0(Hazardous Substances Data)

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H318
Precautionary statements P280-P305+P351+P338

Pyridoxine hydrochloride Price More Price(25)

Brand: Sigma-Aldrich(India)
Product number: P9755
Product name : Pyridoxine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25G
Price: ₹2749.55
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR1036
Product name : Pyridoxine hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: ₹8356.9
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P9755
Product name : Pyridoxine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 100G
Price: ₹8281.13
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P6280
Product name : Pyridoxine hydrochloride
Purity: BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
Packaging: 10G
Price: ₹3972.78
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: P6280
Product name : Pyridoxine hydrochloride
Purity: BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
Packaging: 25G
Price: ₹5011.98
Updated: 2022/06/14
Buy: Buy

Pyridoxine hydrochloride Chemical Properties,Usage,Production

Nutrition supplements
Pyridoxine hydrochloride(58-56-0) is the hydrochloride salt of Vitamin B6. Vitamin B6 (B6) is a water-soluble vitamin, which can be found in various foods such as fish, poultry, whole grains, legumes, banana, nuts, and sesame.Vitamin B6 has an important role in the metabolism of amino acids as a coenzyme, pyridoxal 5'-phosphate.

B6 may exert an anticolon tumor effect by the protection of the colon epithelium from damage in rats treated with 1,2-dimethylhidrazine (DMH) and to decreased lithocholic acid, a colon carcinogen. Vitamin B6 may prevent such diseases by lowering inflammation.
Chemical Properties White or almost white, crystalline powder.
Uses Pyridoxine Hydrochloride is an acid form of vitamin b6, a water- soluble vitamin. it is soluble in water, and slightly soluble in alco- hol. it is slowly affected by sunlight and is reasonably stable in air. it has a ph of 2.3–3.5. it is also termed vitamin b6 hydrochloride. see pyridoxine.
Definition ChEBI: Pyridoxine hydrochloride is the hydrochloride salt of pyridoxine. It is a hydrochloride and a vitamin B6. It contains a pyridoxine.
Application Pyridoxine hydrochloride has been used:
As a vitamin component in a chemically defined diet with balanced metal content for metal depletion studies;
As a component of chemically defined medium (CDM) to culture Staphylococcus aureus WSPPA;
As analytical reference standards for the determination of analytes in pharmaceutical preparations by chromatography and spectrophotometric techniques;
As a vitamin to study the impact of protein expression and post-translational modifications specifically charge heterogeneity;
As a medicine, it is used to prevent or treat certain neurological disorders (peripheral neuropathy) caused by certain drugs (e.g. isoniazid). It is also used in the treatment of certain hereditary disorders (e.g. flavoururic aciduria, hyperoxaluria, homocystinuria).
brand name Hexa-Betalin (Lilly).
General Description Vitamin B6 has six forms namely, pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Pyridoxine hydrochloride primarily treats vitamin B6 deficiency and helps alleviate nausea and vomiting during pregnancy. It exists in various forms, including pyridoxine, pyridoxal, and pyridoxamine, which convert into the active coenzyme pyridoxal 5-phosphate (PLP or P5P) in the body.
Biochem/physiol Actions Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy.
Clinical Use Vitamin B6
Side effects Common side effects of Pyridoxine hydrochloride include: headache, nausea, drowsiness, mild numbness or tingling. Serious allergic reactions are rare and include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing, decreased sensation of touch, temperature, and vibration; loss of balance or coordination. If serious side effects occur please seek medical attention.
Safety Profile Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Metabolism Pyridoxine hydrochloride is metabolised to its active form pyridoxamine phosphate. It is stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine.
Purification Methods Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.]