ChemicalBook > CAS DataBase List > 5-Methyl-1H-pyrazole-3-carboxylic acid

5-Methyl-1H-pyrazole-3-carboxylic acid

CAS No.402-61-9
Chemical Name:5-Methyl-1H-pyrazole-3-carboxylic acid
CBNumber:CB8853600
Molecular Formula:C5H6N2O2
Formula Weight:126.11
MOL File:402-61-9.mol

5-Methyl-1H-pyrazole-3-carboxylic acid Property

Melting point 241 °C
Boiling point 388.8±22.0 °C(Predicted)
Density 1.404±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in dimethyl sulfoxide.
pka 15.36±0.10(Predicted)
form powder to crystal
color White to Yellow to Orange
CAS DataBase Reference 402-61-9(CAS DataBase Reference)
FDA UNII U71778T48T
UNSPSC Code 12352100
NACRES NA.28

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-37/39
WGK Germany :3
RTECS :UQ6407500
HazardClass :IRRITANT
HS Code :29331990

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

5-Methyl-1H-pyrazole-3-carboxylic acid Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 644927
Product name : 3-Methylpyrazole-5-carboxylic acid
Purity: 97%
Packaging: 1G
Price: ₹8984.75
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 644927
Product name : 3-Methylpyrazole-5-carboxylic acid
Purity: 97%
Packaging: 5G
Price: ₹53756.95
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: M2607
Product name : 3-Methylpyrazole-5-carboxylic Acid
Purity:
Packaging: 1G
Price: ₹5200
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: M2607
Product name : 3-Methylpyrazole-5-carboxylic Acid
Purity:
Packaging: 5G
Price: ₹12000
Updated: 2022/05/26
Buy: Buy

5-Methyl-1H-pyrazole-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties White to light yellow solid
Uses 3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.
Definition ChEBI: A memebr of the class of pyrazoles that is 1H-pyrazole with methyl and carboxylic acid group substituents at positions 5 and 3 respectively.
General Description 3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.

in vivo

AS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes?phencyclidine?(PCP)-induced?prepulse inhibition^[1].
AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects^[1].
Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats^[1].

	IV (10 mg/kg)	PO (10 mg/kg)
C₀ (ng/mL)	100,557.3
C_max (ng/mL)	73,559.8	8088.8
t_max (h)	0.083	1
C_Z (ng/mL)	26.8	40.5
t_Z (h)	24	24
AUC_Z (ng/mL·h)	45,596.2	18,254.4
λ_Z (h^-1)	0.124	0.096
AUC (ng/mL·h)	45,810.9	18,649.9
V_Z (L/kg)	1.76
V_SS (L/kg)	0.24
CL (L/kg/h)	0.22
MRT (h)	1.087
F		0.407

Animal Model:	Males C57BL/6J mice^[1]
Dosage:	80 mg/kg, 20 mg/kg
Administration:	PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage
Result:	Normalized?phencyclidine?(PCP)-induced?prepulse inhibition?after acute (80?mg/kg) and chronic (20?mg/kg b.i.d.)?oral administration?in mice.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	10 mg/kg
Administration:	PO and IV; single dosage (Pharmacokinetics Analysis)
Result:	Exhibited good pharmacokinetic effect.

5-Methyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials

Raw materials