Preparation
In a reaction vessel, add 1000 kg of water, 370 kg of acetylacetone, and an appropriate amount of glacial acetic acid. Then, add hydrazine hydrate dropwise, keeping the reaction temperature below 50°C. After all the hydrazine hydrate has been added, maintain the reaction at 50°C for 3 hours. Cool to 10°C, centrifuge, rinse, and vacuum dry to obtain 3,5-dimethylpyrazole.
Chemical Properties
White crystal powder
Uses
Common reagent for the preparation of pyrazolato ligated complexes.1,2 Also used to prepare N-1-substituted derivatives having antibacterial activity.3
Uses
3,5-Dimethylpyrazole his a catalyst in the sulfonation of acetic anhydride to sulfoacetic acid and methanedisulfonic acid. 3,5-Dimethylpyrazole has been used in the synthesis of bipyrazolic tripodal derivatives with in vitro antitumor, antifungal and antibacterial activities.
Uses
3,5-Dimethylpyrazole is used as intermediate for the manufacture of organic dyestuffs and photochemicals. Product Data Sheet
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 19, p. 373, 1982
DOI: 10.1002/jhet.5570190231Organic Syntheses, Coll. Vol. 4, p. 351, 1963
Purification Methods
Crystallise it from cyclohexane or water. [Barszez et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 23/5 V 110.]
