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FK 888

FK 888 Structure
FK 888
  • CAS No.138449-07-7
  • Chemical Name:FK 888
  • CBNumber:CB8785831
  • Molecular Formula:C36H36N4O4
  • Formula Weight:588.7
  • MOL File:138449-07-7.mol
FK 888 Property
  • Boiling point 901.9±65.0 °C(Predicted)
  • Density 1.26±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO: ≥13mg/mL
  • form powder
  • pka 13.01±0.40(Predicted)
  • color white to tan
  • optical activity [α]/D -135 to -145°, c = 1 in methanol
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

FK 888 Chemical Properties,Usage,Production

  • Uses FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.
  • Definition ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide.
  • Biological Activity Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.
  • storage Store at -20°C
FK 888 Preparation Products And Raw materials
Raw materials
Preparation Products
FK 888 Suppliers
Global(26)Suppliers
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FK 888 Spectrum
138449-07-7, FK 888Related Search:
  • 化合物 T22786
  • 138449-07-7
  • FK888 hydrate
  • (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate
  • (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
  • N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide
  • L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
  • L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
  • FK 888
  • N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate

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