ChemicalBook > CAS DataBase List > 1-Methylindole-3-carboxaldehyde

1-Methylindole-3-carboxaldehyde

CAS No.19012-03-4
Chemical Name:1-Methylindole-3-carboxaldehyde
CBNumber:CB1201057
Molecular Formula:C10H9NO
Formula Weight:159.18
MOL File:19012-03-4.mol

1-Methylindole-3-carboxaldehyde Property

Melting point 70-72 °C (lit.)
Boiling point 186-189 °C(Press: 3-4 Torr)
Density 1.10±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystalline Powder and Chunks
color Light yellow to orange or brown
Water Solubility Insoluble in water.
Sensitive Air Sensitive
BRN 121302
CAS DataBase Reference 19012-03-4(CAS DataBase Reference)
FDA UNII Z612E3VMZ5
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-37/39
WGK Germany :3
HazardClass :IRRITANT
HS Code :29339900

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

1-Methylindole-3-carboxaldehyde Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: 357987
Product name : 1-Methylindole-3-carboxaldehyde
Purity: 97%
Packaging: 5G
Price: ₹10922.43
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 357987
Product name : 1-Methylindole-3-carboxaldehyde
Purity: 97%
Packaging: 25G
Price: ₹34564.23
Updated: 2022/06/14
Buy: Buy

Brand: ottokemi
Product number: M 2093
Product name : 1-Methyl-3-formylindole
Purity: 97%
Packaging: 1gm
Price: ₹4005
Updated: 2022/05/26
Buy: Buy

Brand: ottokemi
Product number: M 2093
Product name : 1-Methyl-3-formylindole
Purity: 97%
Packaging: 5gm
Price: ₹9819
Updated: 2022/05/26
Buy: Buy

Brand: ottokemi
Product number: M 2093
Product name : 1-Methyl-3-formylindole
Purity: 97%
Packaging: 25gm
Price: ₹30501
Updated: 2022/05/26
Buy: Buy

1-Methylindole-3-carboxaldehyde Chemical Properties,Usage,Production

Chemical Properties light yellow to orange or brown crystalline powder
Uses Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents.
Uses 1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).
Synthesis Reference(s) Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960
General Description 1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.