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O-Desmethylvenlafaxine

O-Desmethylvenlafaxine Structure
O-Desmethylvenlafaxine
  • CAS No.93413-62-8
  • Chemical Name:O-Desmethylvenlafaxine
  • CBNumber:CB8496834
  • Molecular Formula:C16H25NO2
  • Formula Weight:263.38
  • MOL File:93413-62-8.mol
O-Desmethylvenlafaxine Property
  • Melting point 208-213°C
  • Boiling point 403.8±25.0 °C(Predicted)
  • Density 1.115±0.06 g/cm3(Predicted)
  • Flash point 9℃
  • storage temp. 2-8°C
  • solubility insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
  • form Solid
  • pka 10.04±0.26(Predicted)
  • color White to off-white
  • InChIKey KYYIDSXMWOZKMP-UHFFFAOYSA-N
  • LogP 0.33 at 25℃ and pH6
  • FDA UNII NG99554ANW
  • ATC code N06AX23
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319
  • Precautionary statements P305+P351+P338
O-Desmethylvenlafaxine Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: V-045
  • Product name : O-Desmethylvenlafaxine solution
  • Purity: 1.0?mg/mL in methanol, certified reference material, Cerilliant?
  • Packaging: 1ML
  • Price: ₹39022.2
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: V-007
  • Product name : O-Desmethylvenlafaxine solution
  • Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging: 1ML
  • Price: ₹9615.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 93867
  • Product name : O-Desmethylvenlafaxine
  • Purity: analytical standard
  • Packaging: 50MG
  • Price: ₹11171.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D5598
  • Product name : O-Desmethylvenlafaxine
  • Purity: 
  • Packaging: 1G
  • Price: ₹5100
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D5598
  • Product name : O-Desmethylvenlafaxine
  • Purity: 
  • Packaging: 5G
  • Price: ₹10100
  • Updated: 2022/05/26
  • Buy: Buy

O-Desmethylvenlafaxine Chemical Properties,Usage,Production

  • Description Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.
  • Chemical Properties White Solid
  • Originator Wyeth (United States)
  • Uses A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
  • Uses a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.
  • Uses A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.
  • Definition ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.
  • brand name Pristiq
  • General Description An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
  • Synthesis Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.
O-Desmethylvenlafaxine Preparation Products And Raw materials
Raw materials
Preparation Products
O-Desmethylvenlafaxine Suppliers
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O-Desmethylvenlafaxine Spectrum
93413-62-8, O-DesmethylvenlafaxineRelated Search:
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  • 93413-62-8
  • (±)-O-Desmethyl Venlafaxine
  • <i>O</i>-Desmethylvenlafaxine
  • Effexor Impurity 36
  • O-Desmethylvenlafaxine in methanol
  • O-Desmethyl Venlafaxine (Free base)
  • Venlafaxine O-Desmethyl
  • Venlafxine-O-Desmethyl
  • 93413-62-8 O-Desmethylvenlafaxine
  • DesvenlafaxineQ: What is Desvenlafaxine Q: What is the CAS Number of Desvenlafaxine Q: What is the storage condition of Desvenlafaxine Q: What are the applications of Desvenlafaxine
  • Venlafaxine Impurity 36
  • Desvenlafaxine (WY 45233
  • O-Desmethylvenlafaxine USP/EP/BP
  • D,L-O-Desmethyl Venlafaxine (100 μg/mL in Methanol)
  • O-Desmethylvenlafaxine, 98%, a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor
  • Venlafaxine-d10 HCl O-Desmethyl Venlafaxine-d10
  • Desvenlafaxine impurity C
  • O-Desmethylvenlafaxine(DL)
  • O-Desmethylvenlafaxine solution
  • Desvenlafaxine Base
  • Phenol,4-[2-(diMethylaMino)-1-(1-hydroxycyclohexyl)ethyl]-

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