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D-α-Tocopherol succinate

D-α-Tocopherol succinate Structure
D-α-Tocopherol succinate
  • CAS No.4345-03-3
  • Chemical Name:D-α-Tocopherol succinate
  • CBNumber:CB8483476
  • Molecular Formula:C33H54O5
  • Formula Weight:530.78
  • MOL File:4345-03-3.mol
D-α-Tocopherol succinate Property
  • Melting point ~76 °C(lit.)
  • Boiling point 625.8±55.0 °C(Predicted)
  • Density 1.002±0.06 g/cm3(Predicted)
  • vapor pressure 0Pa at 20℃
  • storage temp. -20°C
  • solubility Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.
  • form Solid
  • pka 4.35±0.17(Predicted)
  • color White or off-white
  • Odor Little or no odor
  • biological source synthetic
  • λmax 286nm(EtOH)(lit.)
  • Merck 14,9495
  • BRN 4038233
  • Specific Activity 1210IU/g
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
  • LogP 12 at 25℃
  • CAS DataBase Reference 4345-03-3(CAS DataBase Reference)
  • Substances Added to Food (formerly EAFUS) ALPHA-TOCOPHEROL ACID SUCCINATE
  • EWG's Food Scores 1
  • FDA UNII LU4B53JYVE
  • EPA Substance Registry System D-.alpha.-Tocopheryl acid succinate (4345-03-3)
  • UNSPSC Code 41116107
  • NACRES NA.79
Safety
  • WGK Germany  :1
  • RTECS  :EJ9984000
  • F  :8-10-23
  • HS Code  :2936280000
  • Toxicity :LD50 oral in rat: > 7gm/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
D-α-Tocopherol succinate Price More Price(9)
  • Brand: Sigma-Aldrich(India)
  • Product number: T3126
  • Product name : D-α-Tocopherol succinate
  • Purity: semisynthetic, 1210?IU/g
  • Packaging: 5G
  • Price: ₹4687.23
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T3126
  • Product name : D-α-Tocopherol succinate
  • Purity: semisynthetic, 1210?IU/g
  • Packaging: 25G
  • Price: ₹13542.08
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T3126
  • Product name : D-α-Tocopherol succinate
  • Purity: semisynthetic, 1210?IU/g
  • Packaging: 100G
  • Price: ₹24334.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR1029
  • Product name : Tocopheryl Acid Succinate, a
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 500MG
  • Price: ₹8356.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 95255
  • Product name : D-α-Tocopherol succinate
  • Purity: BioXtra, ≥98.0% (HPLC)
  • Packaging: 100MG
  • Price: ₹10803.35
  • Updated: 2022/06/14
  • Buy: Buy

D-α-Tocopherol succinate Chemical Properties,Usage,Production

  • Description Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2?Tocopherol succinate induces apoptosis in human gastric cancer cells3?and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5
  • Chemical Properties Off-White to Pale Yellow Solid
  • Uses A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
  • Uses A potent antioxidant tocopherol
  • Definition ChEBI: Tocopherol succinate is a tocol and a hemisuccinate.
  • General Description White powder.
  • Air & Water Reactions Insoluble in water.
  • Reactivity Profile Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
  • Fire Hazard Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible.
  • Flammability and Explosibility Not classified
  • Biochem/physiol Actions Tocopherol exhibits antioxidant property by protecting the cells and membranes from oxidative stress. In plants, high levels of α-tocopherol leads to plant stress tolerance whereas low levels is associated with oxidative stress. In humans, tocopherol prevents cancer, premature aging, atherosclerosis, arthritis caused due to free radicals. Vitamin E succinate (VES) is an anti-tumor analog of vitamin E.
  • Safety Profile When heated to decomposition it emits acrid smoke and irritating fumes.
  • References 1) Singh?et al. (2010),?Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor; Int. J. Radiation Biol.,?86?12 2) Singh?et al. (2009),?Tocopherol succinate: a promising radiation countermeasure; Immunopharmacol.,?9?1423 3) Wu?et al. (2004),?c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells; J. Gastroenterol.,?10?1110 4) Stapelberg?et al. (2004),?alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors; Biochem. Biophys. Res. Commun.,?318?636 5) Swettenham?et al. (2005),?Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system; J. Neurochem.,?94?1448
D-α-Tocopherol succinate Preparation Products And Raw materials
Raw materials
Preparation Products
D-α-Tocopherol succinate Suppliers
Global(328)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
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    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
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D-α-Tocopherol succinate Spectrum
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