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Isoacteoside

Isoacteoside Structure
Isoacteoside
  • CAS No.61303-13-7
  • Chemical Name:Isoacteoside
  • CBNumber:CB8450300
  • Molecular Formula:C29H36O15
  • Formula Weight:624.59
  • MOL File:61303-13-7.mol
Isoacteoside Property
  • Melting point 220～230℃
  • Boiling point 942.9±65.0 °C(Predicted)
  • Density 1.60±0.1 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility DMSO : ≥ 48 mg/mL (76.85 mM)
  • form Powder
  • pka 9.32±0.10(Predicted)
  • color White to yellow
  • biological source plant
  • FDA UNII 588LJK42AP
  • UNSPSC Code 41116107
  • NACRES NA.25
Safety
  • HS Code  :29389090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Isoacteoside Chemical Properties,Usage,Production

  • Description Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml. Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells. It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; ). It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.
  • Uses Isoacteoside is a possible food antioxidant.
  • Definition ChEBI: Isoacteoside is a hydroxycinnamic acid.
  • in vivo

    Isoacteoside (25-100 mg/kg, ip, single dose) exhibits anti-inflammatory efficacy in mouse xylene-induced ear edema models, LPS (HY-D1056)-induced endotoxin shock models, and LPS (HY-D1056)-induced acute kidney injury (AKI) models[2].
    Isoacteoside (30 mg/kg, ip, three times a week for 5 weeks) exhibits antitumor efficacy in mouse OVCAR-3 xenograft models[3].
    Isoacteoside (2.5-5 mg/kg, icv for 15 days) exhibits neuroprotective effect against Aβ 1-42-induced neurotoxicity and cognitive impairment in SD rats models[5].

    Animal Model:Acute kidney injury (AKI) model[2]
    Dosage:25-100 mg/kg
    Administration:ip, single dose
    Result:Ameliorated LPS induced acute kidney injury.
    Animal Model:Mouse OVCAR-3 xenograft model[3]
    Dosage:30 mg/kg
    Administration:ip, three times a week for 5 weeks
    Result:Reduced the tumor weight and volume.
    Animal Model:Aβ 1-42 induced neurotoxicity in Sprague-Dawley rats models[5]
    Dosage:2.5-5 mg/kg
    Administration:icv for 15 days
    Result:Increased the exploratory behavior, shortened the escape latency.
Isoacteoside Preparation Products And Raw materials
Raw materials
Preparation Products
Isoacteoside Suppliers
Global(215)Suppliers
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    BOC Sciences
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Isoacteoside Spectrum
61303-13-7, IsoacteosideRelated Search:
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  • 异麦角甾苷,10 MM DMSO 溶液
  • 异类叶生麻苷
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  • 异类叶升麻苷(对照品)
  • 尾-D-GLUCOPYRANOSIDE,2-(3,4-DIHYDROXYPHENYL)ETHYL3-O-(6-DEOXY-伪-L-MANNOPYRANOSYL)-,6-[(2E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE]
  • (E)-(((2R,3R,4S,5R,6R)-6-(3,4-二羟基苯乙氧基)-3,5-二羟基-4-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)甲基3-(3,4-二羟基苯基)丙烯酸酯
  • 异毛蕊花苷
  • 异麦角兹苷
  • 异麦角甾苷(异类叶升麻苷)对照品,
  • ISOACTEOSIDE 异类叶升麻苷
  • 异麦角兹苷,异毛蕊花糖苷
  • 异类叶升麻苷(标准品)
  • 异毛蕊花糖苷、异类叶升麻苷
  • 异毛蕊花糖苷
  • 异类叶升麻苷(异麦角甾苷)
  • 异类叶升麻苷
  • 异毛蕊花糖苷(标准品)
  • 异类叶升麻苷/异毛蕊花糖苷
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  • 异麦角甾苷
  • 异类叶升麻苷(异麦角甾苷,异毛蕊花糖苷)
  • 61303-13-7
  • Isoacteoside, 10 mM in DMSO
  • [(2R,3R,4S,5R,6R)-5-(3,4-Dihydroxyphenyl)-6-ethoxy-Chemicalbook3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3
  • ((2R,3R,4S,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-3,5-dihydroxy-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl (E)-3-(3,4-dihydroxyphenyl)acrylate
  • [(2R,3R,4S,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • Isoacteoside (Isoverbascoside)
  • Isoacteoside，HPLC≥98%
  • 3,4-Dihydroxyphenethyl 3-O-α-L-rhamnopyranosyl-6-O-(3,4-dihydroxycinnamoyl)-β-D-glucopyranoside
  • 2-(3,4-Dihydroxyphenyl)ethyl 3-O-α-L-rhamnopyranosyl-6-O-(3,4-dihydroxycinnamoyl)-β-D-glucopyranoside
  • 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(α-L-rhamnopyranosyl)-6-O-[(E)-3-(3,4-dihydroxyphenyl)acryloyl]-β-D-glucopyranoside
  • 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(α-L-rhamnopyranosyl)-6-O-[(E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-β-D-glucopyranoside
  • [(2R,3R,4S,5R,6R)-5-(3,4-Dihydroxyphenyl)-6-ethoxy-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • Isoacteosid
  • ISOACTEOSIDE
  • ISOVERBASCOSIDE

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