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APRINDINE HCL

APRINDINE HCL Structure
APRINDINE HCL
  • CAS No.33237-74-0
  • Chemical Name:APRINDINE HCL
  • CBNumber:CB8440044
  • Molecular Formula:C22H31ClN2
  • Formula Weight:358.95
  • MOL File:33237-74-0.mol
APRINDINE HCL Property
  • Melting point 120-121°
  • storage temp. 2-8°C
  • solubility H2O: >10mg/mL
  • form solid
  • color Light Brown to Brown
  • Water Solubility H2O: >10mg/mL
  • Stability Hygroscopic
  • FDA UNII PB5EKT7Q2V
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-36/37/38
  • Safety Statements  :26
  • WGK Germany  :3
  • RTECS  :TX7386000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
APRINDINE HCL Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: A7606
  • Product name : Aprindine hydrochloride
  • Purity: ≥98% (HPLC), solid
  • Packaging: 10MG
  • Price: ₹17547.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A7606
  • Product name : Aprindine hydrochloride
  • Purity: ≥98% (HPLC), solid
  • Packaging: 50MG
  • Price: ₹70113.53
  • Updated: 2022/06/14
  • Buy: Buy

APRINDINE HCL Chemical Properties,Usage,Production

  • Originator Amidonal,Madaus,W. Germany,1976
  • Uses Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.
  • Definition ChEBI: Aprindine hydrochloride is a member of indanes.
  • Manufacturing Process 104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen. 37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3 hours at room temperature.
    119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After agitation during 1 hour at room temperature, the reaction mixture is refluxed and stirred under nitrogen during 21 hours. The mixture is then allowed to cool and poured onto ice. The obtained aqueous phase is extracted by means of 500 cm3 of benzene. The benzene extract is washed two times with 200 cm3 of water and the benzene is then evaporated.
    The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained solution is evaporated to dryness and the oily residue is recrystallized from ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl- 2-aminoindane are obtained, MP 208° to 210°C.
    The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g (0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous solution to dryness, drying by means of benzene, filtering the formed sodium chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g (95%) of monohydrochloride are obtained, MP 120° to 121°C.
  • brand name Fibocil (Lilly).
  • Therapeutic Function Antiarrhythmic
  • Biological Activity Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3μ:5μ-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
APRINDINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
APRINDINE HCL Suppliers
Global(50)Suppliers
  • Supplier：
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  • Supplier：
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier： J & K SCIENTIFIC LTD.
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APRINDINE HCL Spectrum
33237-74-0, APRINDINE HCLRelated Search:
  • pharmacetical
  • 抑制剂
  • 医药原料
  • 原料药
  • 35895
  • C22H30N2HCl
  • C22H31ClN2
  • 化合物 APRINDINE HYDROCHLORIDE
  • 化合物 T21373
  • 盐酸茚丙胺APRINDINE HYDROCHLORIDE
  • APRINDINE 盐酸盐
  • 盐酸阿普林定
  • 盐酸茚丙胺
  • 33237-74-0
  • Fibocil
  • Aprindina
  • APRINDINE HCL ISO 9001：2015 REACH
  • aspenon
  • 3-propanediamine,n,n-diethyl-n’-2-indanyl-n’-phenyl-monohydrochloride
  • 3-propanediamine,n-(2,3-dihydro-1h-inden-2-yl)-n’,n’-diethyl-n-phenyl-mo
  • Compound 83846
  • N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride
  • Amidonal
  • N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenylpropane-1,3-diamine monohydrochloride
  • APRINDINE HYDROCHLORIDE
  • APRINDINE HCL
  • n,n-diethyl-n’-2-indanyl-n’-phenyl-1,3-propanediaminehydrochloride
  • n-(3-(diethylamino)propyl)-n-phenyl-2-indanaminhydrochloride
  • ms-5075
  • fiboran

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