Pharmaceutical Applications
N-Methylglucamine antimonate; methylaminoglucitol antimonate.
The Sb
V content varies around 28% between batches.
The major moieties are Sb
V–ligand complexes which are zwitterionic
in solution.
The activity, pharmacology and toxicology are similar to
those of sodium stibogluconate, with which it is essentially
interchangeable.
Clinical Use
Treatment of visceral and cutaneous leishmaniasis
Studies in Central and South America have indicated that the
combination with interferon-γ is effective in the treatment of
visceral and cutaneous leishmaniasis cases unresponsive to
antimony alone.
