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Erythromycin stearate

Erythromycin stearate Structure
Erythromycin stearate
  • CAS No.643-22-1
  • Chemical Name:Erythromycin stearate
  • CBNumber:CB2436793
  • Molecular Formula:C55H103NO15
  • Formula Weight:1018.42
  • MOL File:643-22-1.mol
Erythromycin stearate Property
  • Melting point 77-79°C
  • storage temp. 2-8°C
  • solubility ethanol: soluble50mg/mL, clear to very slightly hazy, colorless
  • color white to off-white
  • Stability Stable. Combustible. Incompatible with acids, strong oxidizing agents.
  • FDA UNII LXW024X05M
  • EPA Substance Registry System Erythromycin stearate (643-22-1)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H317-H334
  • Precautionary statements P261-P272-P280-P284-P302+P352-P304+P340+P312

Erythromycin stearate Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Erythrocin Stearate,Abbott,US,1952
  • Uses Macrodiles antibacterial
  • Uses oil lubricant, plasticizer, solvent
  • Uses Semi-synthetic macrolide antibiotic. Antibacterial
  • Definition ChEBI: Erythromycin stearate is an aminoglycoside.
  • Manufacturing Process To a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and 1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete solution is obtained and stirring is then discontinued. The solution is allowed to stand overnight. The solution is diluted to 250 ml by the addition of methylene chloride and washed three times with 100 ml portions of water followed by two washes with 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and filtered, the solvent being removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.
  • brand name Bristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).
  • Therapeutic Function Antibacterial
  • General Description Erythromycin stearate (Ethril, Wyamycin S, Erypar) is thestearic acid salt of erythromycin. Like erythromycin base,the stearate is acid labile. It is film coated to protect it fromacid degradation in the stomach. In the alkaline pH of theduodenum, the free base is liberated from the stearateand absorbed. Erythromycin stearate is a crystalline powderthat is practically insoluble in water but soluble in alcoholand ether.
  • General Description Fluffy colorless powder or fine white powder.
  • Air & Water Reactions Insoluble in water.
  • Reactivity Profile A base. Readily forms salts with acids.
  • Fire Hazard Flash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.
Erythromycin stearate Preparation Products And Raw materials
Raw materials
Preparation Products
Erythromycin stearate Suppliers
Global(215)Suppliers
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Erythromycin stearate Spectrum
643-22-1, Erythromycin stearate Related Search:
  • Organics
  • Spectrum of Activity
  • Mechanism of Action
  • Macrolides
  • Interferes with Protein SynthesisAntibiotics
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  • A - KAntibiotics
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  • Antibiotics A to Z
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  • BioChemical
  • C55H101NO14
  • C55H103NO15
  • C37H67NO13C18H36O2
  • 硬脂酸红霉素/A1A
  • 硬脂酸红霉素 USP标准品
  • 硬脂酸红霉素 EP标准品
  • 红霉素硬脂酸酯
  • 红霉素硬脂酸
  • 硬脂酸盐
  • 硬酯酸红霉素
  • 红霉素硬脂酸盐
  • 硬脂酸红霉素
  • 643-22-1
  • gallimycin
  • erypar
  • bristamycin
  • pfizer-e
  • Erythromycin Stearate (1248006)
  • Erythromycin stearate for impurity S identification (Y0001849)
  • TIANFU-CHEM -Erythromycin stearate
  • Erythromycin stearateQ: What is Erythromycin stearate Q: What is the CAS Number of Erythromycin stearate Q: What is the storage condition of Erythromycin stearate Q: What are the applications of Erythromycin stearate
  • Erythromycin Stearate (secondary standard)Q: What is Erythromycin Stearate (secondary standard) Q: What is the CAS Number of Erythromycin Stearate (secondary standard) Q: What is the storage condition of Erythromycin Stearate (secondary standard)
  • Erythromycin stearate USP/EP/BP

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