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Polyoxyethylene stearate

CAS No.9004-99-3
Chemical Name:Polyoxyethylene stearate
CBNumber:CB4111623
Molecular Formula:(C2H4O)nC18H36O2
Formula Weight:622.91
MOL File:9004-99-3.mol

Polyoxyethylene stearate Property

Melting point 47 °C
Flash point 39 °C
storage temp. 2-8°C
Water Solubility Soluble in water
solubility Chloroform (Slighty), Methanol (Slightly)
form powder to lump
color White to Almost white
Odor at 100.00?%. mild fatty
Hydrophilic-Lipophilic Balance (HLB) 18.8
LogP 7.629 (est)
Substances Added to Food (formerly EAFUS) POLYOXYETHYLENE 40 MONOSTEARATE
FDA 21 CFR 173.340; 176.170; 177.1200
EWG's Food Scores 1-3
FDA UNII 7TB32G765E
EPA Substance Registry System Polyethylene glycol monostearate (9004-99-3)
Cosmetics Info PEG-100 Stearate
UNSPSC Code 41116107
NACRES NA.25

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :1
RTECS :MD0907300
HS Code :3907200000
Hazardous Substances Data :9004-99-3(Hazardous Substances Data)
Toxicity :LD50 oral in rabbit: > 12mL/kg

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P305+P351+P338

Polyoxyethylene stearate Price More Price(15)

Brand: Sigma-Aldrich(India)
Product number: P3440
Product name : Polyoxyethylene (40) stearate
Purity:
Packaging: 250G
Price: ₹3474.3
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0723
Product name : Polyethylene Glycol Monostearate (n=approx. 55) (palmitate and stearate mixture)
Purity:
Packaging: 25G
Price: ₹1800
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0723
Product name : Polyethylene Glycol Monostearate (n=approx. 55) (palmitate and stearate mixture)
Purity:
Packaging: 500G
Price: ₹4200
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0722
Product name : Polyethylene Glycol Monostearate (n=approx. 45) (palmitate and stearate mixture)
Purity:
Packaging: 25G
Price: ₹2000
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0722
Product name : Polyethylene Glycol Monostearate (n=approx. 45) (palmitate and stearate mixture)
Purity:
Packaging: 500G
Price: ₹5200
Updated: 2022/05/26
Buy: Buy

Polyoxyethylene stearate Chemical Properties,Usage,Production

Chemical Properties Waxy, light-tan solid; nearly odorless. Congealing range 39–45C. Soluble in water, alcohol, ether, and acetone; insoluble in mineral and vegetable oils.
Uses Polyoxyethylene stearate is an emulsifier and antifoaming agent used in processed foods, fruit jellies, and sauces.
Uses Pegosperse(R) 1500 MS is a mixture of polyethylene glycol esters. It is compatible with lipophilic compounds due to a higher free fatty acid content. Suggested applications: cosmetic formulations, lubricants.
Pegosperse(R) 1750 MS is a high molecular weight, high HLB surface active agent suggested for use in cosmetic formulations (emulsifier, viscosity modifier) and lubricants (emulsifier).
Pegosperse(R) 400 MS is a multifunctional surface active agent suggested for use in cosmetic formulations, household products, lubricants, textile chemicals, polishes and paper.
PEG-5 stearate, an emulsifier, is listed as particularly applicable for hand and body lotions and creams.
Definition Polyoxyethylene stearate is a mixture of the monoand diesters of stearic acid and mixed polyoxyethylene diols having an average polymer length of 7.5 oxyethylene units.
brand name Myrj 53 (ICI Americas).
General Description Polyoxyethylene (40) stearate is a neutral surfactant.
Safety Profile Very slightly toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also other polyethylene glycol monostearate entries and POLYETHYLENE GLYCOL.
in vitro Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and, as such, has been shown to enhance the growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate.
in vivo Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumour volume and weight are significantly less in the polyoxyethylene 40 stearate+vinblastine groups. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group).