643-22-1

Name	Erythromycin stearate
CAS	643-22-1
EINECS(EC#)	211-396-1
Molecular Formula	C55H103NO15
MDL Number	MFCD00084690
Molecular Weight	1018.4
MOL File	643-22-1.mol

Chemical Properties

Appearance	White Solid
Melting point	77-79°C
storage temp.	2-8°C
solubility	ethanol: soluble50mg/mL, clear to very slightly hazy, colorless
form	neat
color	white to off-white
Stability:	Stable. Combustible. Incompatible with acids, strong oxidizing agents.
EPA Substance Registry System	Erythromycin octadecanoate (salt)(643-22-1)

Safety Data

Hazard Codes	Xn,Xi
Risk Statements	42/43-36/37/38 less more
Safety Statements	36-26 less more
WGK Germany	2
RTECS	KF5785000
HS Code	29415000
Hazardous Substances Data	643-22-1(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Solid

Uses

Macrodiles antibacterial

Uses

oil lubricant, plasticizer, solvent

Uses

Semi-synthetic macrolide antibiotic. Antibacterial

General Description

Fluffy colorless powder or fine white powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A base. Readily forms salts with acids.

Fire Hazard

Flash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.

Originator

Erythrocin Stearate,Abbott,US,1952

Definition

ChEBI: Erythromycin stearate is an aminoglycoside.

Manufacturing Process

To a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and 1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete solution is obtained and stirring is then discontinued. The solution is allowed to stand overnight. The solution is diluted to 250 ml by the addition of methylene chloride and washed three times with 100 ml portions of water followed by two washes with 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and filtered, the solvent being removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.

Brand name

Bristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).

Therapeutic Function

Antibacterial

Material Safety Data Sheet(MSDS)

Supplier

Taishan City Chemical Pharmaceutical Co.,Ltd.

Telephone0750-5553232 5675028

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList9082/0.htm

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

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future industrial shanghai co., ltd

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TAIYUAN RHF CO.,LTD.

Telephone+86 351 7031519

Websitehttp://www.rhfchem.com/

Chemsky（shanghai）International Co.,Ltd.

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XiaoGan ShenYuan ChemPharm co,ltd

Telephone 15527768850

Websitehttp://www.farchem.com/

Sichuan Kulinan Technology Co., Ltd

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Websitehttp://www.hx-r.com/

Sinopharm Chemical Reagent Co,Ltd.

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Websitehttp://www.reagent.com.cn

Dalian Meilun Biotech Co., Ltd.

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Websitehttp://www.meilune.com/

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai T&W Pharmaceutical Co., Ltd.

Telephone+86 21 61551611

Websitehttp://www.trustwe.com

The future of Shanghai Industrial Co., Ltd.

Telephone021-61552785

Websitehttp://www.jonln.com

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

Wuhan DKY Technology Co.,Ltd.

Telephone27-81302488 18007166089

Websitehttp://www.wuhandky.com

Shanghai JONLN Reagent Co., Ltd.

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Websitehttp://www.jonln.com

Taizhou Creating Chemical Co., Ltd

Telephone0576-88827176 18906581668

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList6306/0.htm

Suzhou yacoo science co.,Ltd

Telephone0512-87182056 18013166090

Websitehttp://www.yacoo.com.cn

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