Chemical Properties
White Solid
Uses
Macrodiles antibacterial
Uses
oil lubricant, plasticizer, solvent
Uses
Semi-synthetic macrolide antibiotic. Antibacterial
General Description
Fluffy colorless powder or fine white powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A base. Readily forms salts with acids.
Fire Hazard
Flash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.
Originator
Erythrocin Stearate,Abbott,US,1952
Definition
ChEBI: Erythromycin stearate is an aminoglycoside.
Manufacturing Process
To a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and
1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is
added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete
solution is obtained and stirring is then discontinued. The solution is allowed
to stand overnight. The solution is diluted to 250 ml by the addition of
methylene chloride and washed three times with 100 ml portions of water
followed by two washes with 5% sodium bicarbonate solution. The organic
layer is dried over anhydrous sodium sulfate and filtered, the solvent being
removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.
Brand name
Bristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).
Therapeutic Function
Antibacterial
