Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Erythromycin stearate (643-22-1)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Erythromycin stearate
Synonyms
(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione octadecanoic acid
Bristamycin
Dowmycin E
Eratrex
Erypar
Erythromycin, octadecanoate
CAS
643-22-1
Formula
C55H103NO15
Molecular Weight
1018.42
EINECS
211-396-1
RTECS
KF5785000
RTECS Class
Tumorigen; Human Data
Merck
12,3726
Beilstein/Gmelin
4115882

Physical and Chemical Properties

Appearance
Fluffy colorless powder or fine white powder.
Solubility in water
practically insoluble
Melting Point
103 - 107
Usage
Antibiotic.

First Aid Measures

Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Symptoms of exposure to this compound include nausea, vomiting, diarrhea and abdominal cramps. Chronic overexposure may cause jaundice. This may be accompanied by fever, leukocytosis, eosinophilia and elevated activities of transaminases in plasma. Allergic reactions to this compound may include fever, eosinophilia, skin eruptions, urticaria and anaphylaxis. Cholestatic hepatitis occurs rarely. Epigastric distress, possibly severe may also occur. Intramuscular injections of large quantities of this compound may cause extremely severe pain that persists for hours. Intravenous infusions of 1 gram doses have reportedly been followed by thrombophlebitis. Prolonged use may result in an overgrowth of nonsusceptible bacteria or fungi. There have been isolated reports of reversible hearing loss occurring after exposure to this chemical, chiefly in persons with renal insufficiency.
Skin
Contact dermatitis, fixed drug eruptions, toxic pustuloderma, and toxic epidermal necrolysis are uncommon side effects which may occur with macrolide use.
Eyes
See inhalation
Ingestion
See inhalation.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Exposure Effects
Vital sign changes, while rare, may include reduced body temperature and abnormally low blood pressure. sensorineural hearing loss may occur in patients receiving treatment with large doses of macrolide antibiotics, especially in patients suffering from concomitant liver and/or kidney disease. The hearing loss is usually reversible upon discontinuation of the drug. Exacerbation of myasthenia gravis may occur infrequently following erythromycin administration. Pyloric stenosis has been associated with the ingestion of erythromycin through breastmilk.

Fire Fighting Measures

Fire Fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire Potential
This material is probably combustible.

Accidental Release Measures

Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability
No data.
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