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Erythromycin stearate

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Erythromycin stearate Basic information
Erythromycin stearate Chemical Properties
  • Melting point:77-79°C
  • storage temp. 2-8°C
  • solubility ethanol: soluble50mg/mL, clear to very slightly hazy, colorless
  • form neat
  • color white to off-white
  • Stability:Stable. Combustible. Incompatible with acids, strong oxidizing agents.
  • EPA Substance Registry SystemErythromycin stearate (643-22-1)
Safety Information
MSDS
Erythromycin stearate Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • OriginatorErythrocin Stearate,Abbott,US,1952
  • UsesSemi-synthetic macrolide antibiotic. Antibacterial
  • Usesoil lubricant, plasticizer, solvent
  • UsesMacrodiles antibacterial
  • Manufacturing ProcessTo a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and 1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete solution is obtained and stirring is then discontinued. The solution is allowed to stand overnight. The solution is diluted to 250 ml by the addition of methylene chloride and washed three times with 100 ml portions of water followed by two washes with 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and filtered, the solvent being removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.
  • brand nameBristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).
  • Therapeutic FunctionAntibacterial
  • General DescriptionErythromycin stearate (Ethril, Wyamycin S, Erypar) is thestearic acid salt of erythromycin. Like erythromycin base,the stearate is acid labile. It is film coated to protect it fromacid degradation in the stomach. In the alkaline pH of theduodenum, the free base is liberated from the stearateand absorbed. Erythromycin stearate is a crystalline powderthat is practically insoluble in water but soluble in alcoholand ether.
  • General DescriptionFluffy colorless powder or fine white powder.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileA base. Readily forms salts with acids.
  • Fire HazardFlash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.
Erythromycin stearate Preparation Products And Raw materials
Erythromycin stearate (643-22-1)Related Product Information
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