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N-NITROSODIETHANOLAMINE

CAS No.1116-54-7
Chemical Name:N-NITROSODIETHANOLAMINE
CBNumber:CB8401443
Molecular Formula:C4H10N2O3
Formula Weight:134.13
MOL File:1116-54-7.mol

N-NITROSODIETHANOLAMINE Property

Melting point 200 °C (decomp)
Boiling point bp0.01 125°
Density 1,26 g/cm³
refractive index nD20 1.4849
Flash point 11℃
storage temp. 2-8°C
Water Solubility Completely miscible in water
solubility DMSO (Soluble), Ethyl Acetate (Sparingly), Methanol (Soluble), Water (Sparingly)
form clear liquid to slightly cloudy liquid
pka 13.76±0.10(Predicted)
color Light yellow to Brown
Merck 14,6634
BRN 1762620
CAS DataBase Reference 1116-54-7(CAS DataBase Reference)
FDA UNII 30YI1289VY
Proposition 65 List n-Nitrosodiethanolamine
IARC 2B (Vol. 17, Sup 7, 77) 2000
EPA Substance Registry System N-Nitrosodiethanolamine (1116-54-7)

Safety

Hazard Codes :T,F
Risk Statements :45-11
Safety Statements :53-45-16
RIDADR :UN 1993 3/PG 2
WGK Germany :1
RTECS :KL9550000
HS Code :2922.19.9690
HazardClass :3.1
PackingGroup :II
Hazardous Substances Data :1116-54-7(Hazardous Substances Data)
Toxicity :LD50 orl-rat: 7500 mg/kg GISAAA 40(1),81,75

NFPA 704:

	3
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H319-H350
Precautionary statements P201-P210-P305+P351+P338-P308+P313

N-NITROSODIETHANOLAMINE Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: N7632
Product name : N-Nitrosodiethanolamine
Purity:
Packaging: 500MG
Price: ₹9450.23
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: N7632
Product name : N-Nitrosodiethanolamine
Purity:
Packaging: 1G
Price: ₹16486.48
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: N0438
Product name : N-Nitrosodiethanolamine
Purity: min. 97.0 %
Packaging: 5G
Price: ₹17500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: N0438
Product name : N-Nitrosodiethanolamine
Purity: min. 97.0 %
Packaging: 25G
Price: ₹30600
Updated: 2022/05/26
Buy: Buy

N-NITROSODIETHANOLAMINE Chemical Properties,Usage,Production

Chemical Properties Reddish Yellow Oil
Uses A potent liver carcinogen in several species of animals, is one of the most widespread N-nitroso compounds in the human environment.
Definition ChEBI: N-Nitrosodiethanolamine is a nitroso compound.
General Description Yellow to dark brown very viscous liquid with no distinct odor.
Air & Water Reactions Water soluble.
Reactivity Profile N-NITROSODIETHANOLAMINE can react with alkoxides. N-NITROSODIETHANOLAMINE reacts with sulfuric acid at temperatures above 311° F.
Health Hazard ACUTE/CHRONIC HAZARDS: N-NITROSODIETHANOLAMINE may be harmful by eye or skin contact, inhalation or ingestion. It is an irritant and, when heated to decomposition, it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.
Fire Hazard Flash point data for N-NITROSODIETHANOLAMINE are not available; however, N-NITROSODIETHANOLAMINE is probably combustible.
Safety Profile Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data.Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and ALCOHOLS.
Carcinogenicity N-Nitrosodiethanolamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Purification Methods Purify NDELA by dissolving the amine (0.5g) in 1-propanol (10mL) and 5g of anhydrous Na2SO4 added with stirring. After standing for 1-2hours, it is filtered and passed through a chromatographic column packed with 10mL of AG 50W x 8 (H+form 50-100mesh, a strongly acidic cation exchanger). The eluent and washings (50 mL EtOH) are combined and evaporated to dryness at 35o. It has also been extracted with EtOH from the nitrosation mixture of ethanolamine, filtered and distilled under high vacuum. [Fukuda et al. Anal Chem 53 2000 1981, Jones & Wilson J Chem Soc 550, 1949, Beilstein 1 III 721, see Spiegelhalder et al. N-Nitroso Compounds: Occurrence Biological Effects and Relevance in Human Cancer (eds. O’Neill et al. IARC Scientific Publications No 57; IARC Lyon p943 1984.] Possible
Toxics Screening Level The Initial Risk Screening Level (IRSL) for n-nitrosodiethanolamine is 0.0012 μg/m3 based on an annual averaging time.