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N-NITROSODIETHYLAMINE

CAS No.55-18-5
Chemical Name:N-NITROSODIETHYLAMINE
CBNumber:CB8732709
Molecular Formula:C4H10N2O
Formula Weight:102.14
MOL File:55-18-5.mol

N-NITROSODIETHYLAMINE Property

Melting point <25℃
Boiling point 177 °C (lit.)
Density 0.95 g/mL (lit.)
vapor pressure 1.7 mmHg at 20 °C
refractive index n20/D 1.437
storage temp. 2-8°C
solubility Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly)
form liquid
pka -3.14±0.70(Predicted)
color yellow
Water Solubility 106.2g/L(24 ºC)
Merck 6636
BRN 1744991
Stability Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
CAS DataBase Reference 55-18-5(CAS DataBase Reference)
EWG's Food Scores 4-7
FDA UNII 3IQ78TTX1A
Proposition 65 List n-Nitrosodiethylamine
IARC 2A (Vol. 17, Sup 7) 1987
EPA Substance Registry System N-Nitrosodiethylamine (55-18-5)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :T,F
Risk Statements :45-22-39/23/24/25-23/24/25-11
Safety Statements :53-45-36/37-16
RIDADR :UN 2810 6.1/PG 3
WGK Germany :3
RTECS :IA3500000
HazardClass :6.1(b)
PackingGroup :III
HS Code :29299090
Hazardous Substances Data :55-18-5(Hazardous Substances Data)
Toxicity :LD50 oral (rat) 280 mg/kg

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301-H350-H412
Precautionary statements P202-P264-P270-P273-P280-P301+P310

N-NITROSODIETHYLAMINE Price More Price(8)

Brand: Sigma-Aldrich(India)
Product number: N0756
Product name : N-Nitrosodiethylamine
Purity: liquid
Packaging: 10ML
Price: ₹17146.8
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: N0756
Product name : N-Nitrosodiethylamine
Purity: liquid
Packaging: 25ML
Price: ₹34542.58
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: N0258
Product name : N-Nitrosodiethylamine
Purity: ISOPAC?
Packaging: 1G
Price: ₹9655.9
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 73861
Product name : N-Nitrosodiethylamine
Purity: ≥99.0% (GC)
Packaging: 10ML
Price: ₹17255.05
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 442687
Product name : N-Nitrosodiethylamine
Purity: analytical standard
Packaging: 1000MG
Price: ₹12708.55
Updated: 2022/06/14
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N-NITROSODIETHYLAMINE Chemical Properties,Usage,Production

Chemical Properties N-Nitrosodiethylamine is a yellow liquid.
Uses N,N-diethylnitrous Amide is a useful research reagent for organic synthesis.
Uses Gasoline and lubricant additive; antioxidant; stabilizer in plastics.
Uses N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
Definition ChEBI: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
General Description Clear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
Air & Water Reactions Water soluble.
Reactivity Profile N-NITROSODIETHYLAMINE reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid .
Hazard Possible carcinogen; mutagen; neoplastigen; tumorigen; poison; teratogen.
Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSODIETHYLAMINE emits toxic fumes of nitrogen oxides.
Health Hazard The acute toxicity of diethylnitrosamine is classified as moderate. Other nitrosamines of higher molecular weight are somewhat less toxic. Harmful exposure to nitrosamines can occur by inhalation and ingestion and may cause nausea, vomiting, and fever. This substance does not have adequate warning properties. Chronic exposure to nitrosamines can cause severe liver damage. Diethylnitrosamine is listed in IARC Group 2A ("probable human carcinogen") and is classified as an OSHA "select carcinogen." Nitrosamines are suspected of causing cancers of the lung, nasal sinuses, brain, esophagus, stomach, liver, bladder, and kidney. Diethylnitrosamine is mutagenic and teratogenic.
Fire Hazard Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Fire Hazard N-NITROSODIETHYLAMINE is combustible.
Flammability and Explosibility Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Biochem/physiol Actions N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.
Safety Profile Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.
Potential Exposure An additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
Carcinogenicity N-Nitrosodiethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
storage work with diethylnitrosamine should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact.
Shipping UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Incompatibilities An additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations.