General Description
Clear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
Reactivity Profile
N-NITROSODIETHYLAMINE(55-18-5) reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid .
Air & Water Reactions
Water soluble.
Hazard
Possible carcinogen; mutagen; neoplastigen; tumorigen; poison; teratogen.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides.
Potential Exposure
An additive in gasoline and lubricants;
an antioxidant and stabilizer in plastics. Used in research.
Incompatibilities: Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Contact with reducing
agents may form hydrazine; hydrogen bromide. Light sensitive;
rapidly decomposes.
Fire Hazard
This chemical is combustible.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN3082 Environmentally hazardous
substances, liquid, n.o.s., Hazard Class: 9; Labels:
9-Miscellaneous hazardous material, Technical Name
Required.
Incompatibilities
An additive in gasoline and lubricants;
an antioxidant and stabilizer in plastics. Used in research.
Incompatibilities: Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Contact with reducing
agents may form hydrazine; hydrogen bromide. Light sensitive;
rapidly decomposes.
Chemical Properties
N-Nitrosodiethylamine is a yellow liquid.
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Under 40 CFR 261.5 small quantity generators of this
waste may qualify for partial exclusion from hazardous
waste regulations.
Uses
Gasoline and lubricant additive; antioxidant; stabilizer in plastics.
Uses
N,N-diethylnitrous Amide is a useful research reagent for organic synthesis.
Uses
N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
Definition
ChEBI: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Flammability and Explosibility
Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Biochem/physiol Actions
N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.
Carcinogenicity
N-Nitrosodiethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
storage
work with diethylnitrosamine should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact.
