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NS 1619

NS 1619 Structure
NS 1619
  • CAS No.153587-01-0
  • Chemical Name:NS 1619
  • CBNumber:CB8359809
  • Molecular Formula:C15H8F6N2O2
  • Formula Weight:362.23
  • MOL File:153587-01-0.mol
NS 1619 Property
  • Density 1.563±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,2-8°C
  • solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
  • pka 8.32±0.48(Predicted)
  • form solid
  • color white
  • Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL
    ethanol: 26.6mg/mL
    0.1 M NaOH: 5.2mg/mL
    DMSO: 5.3mg/mL
    H2O: insoluble
  • UNSPSC Code 12352200
  • NACRES NA.32
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
NS 1619 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: N170
  • Product name : NS 1619
  • Purity: powder
  • Packaging: 5MG
  • Price: ₹12230
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: N170
  • Product name : NS 1619
  • Purity: powder
  • Packaging: 25MG
  • Price: ₹49340
  • Updated: 2022/06/14
  • Buy: Buy

NS 1619 Chemical Properties,Usage,Production

  • Uses NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.
  • Definition ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
  • Biochem/physiol Actions NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
  • in vivo

    Opening of KCa channels with NS-1619 (1 mg/kg; i.p.) can delay protection in mouse hearts[3].

    Animal Model:Adult male outbred ICR mice[3]
    Dosage:1 mg/kg
    Administration:Pretreated i.p. 24 h before I/R
    Result:Pretreatment induced delayed protection 24 h later.
    Resulted in significant cardioprotection 24 h later, i.e., infarct size was reduced from 38.8 ± 3.7% to 19.8 ± 2.9%.
  • storage +4°C
NS 1619 Preparation Products And Raw materials
Raw materials
Preparation Products
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NS 1619 Spectrum
153587-01-0, NS 1619Related Search:
  • API
  • 抑制剂
  • 药靶配体
  • 合成
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
  • Ion Channels
  • Monovalent Ion Channels
  • C15H8F6N2O2
  • 化合物NS 1619,10 MM DMSO 溶液
  • NS 1619,KCA1.1 CHANNEL活化剂
  • NS-1619,K CA 1.1通道激活剂
  • 5-(TRIFLUOROMETHYL)-1-(5-(TRIFLUOROMETHYL)-2-HYDROXYPHENYL)-1H-BENZO[D]IMIDAZOL-2(4H)-ONE
  • 化合物NS 1619
  • 1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[D]咪唑-2(3H)-酮
  • 153587-01-0
  • NS-1619, 10 mM in DMSO
  • NS 1619, KCa1.1 channel activator
  • 1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol
  • 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
  • 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
  • 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-
  • NS 161
  • NS1619;NS 1619
  • 1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b
  • 1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one
  • 1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
  • NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN
  • NS 1619

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