Uses
PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].
Biological Activity
Novel antagonist selective for the vascular form of K ATP channel; inhibits K ATP currents in isolated mesenteric artery smooth muscle cells (K d = 65 nM) but not in cardiac or skeletal myocytes. In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil. Displays weak diuretic effects.
storage
room temperature (desiccate)
References
[1] Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. DOI:
10.1038/sj.bjp.0705228[2] Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. DOI:
10.1111/j.1527-3466.2006.00025.x[3] Guang-Yuan Mar, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. Int J Exp Pathol. 2013 Feb;94(1):17-24. DOI:
10.1111/iep.12000
