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PENITREM A

PENITREM A Structure
PENITREM A
  • CAS No.12627-35-9
  • Chemical Name:PENITREM A
  • CBNumber:CB4155421
  • Molecular Formula:C37H44ClNO6
  • Formula Weight:634.2
  • MOL File:12627-35-9.mol
PENITREM A Property
  • Melting point 238°C
  • Density 1.0241 (rough estimate)
  • refractive index 1.6000 (estimate)
  • storage temp. 2-8°C
  • solubility Soluble in DMSO (up to 6 mg/ml)
  • form White solid.
  • pka 13.22±0.70(Predicted)
  • color Amorphous solid
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
  • EWG's Food Scores 1
  • FDA UNII 244AU85PR7
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :T+,T
  • Risk Statements  :26/27/28
  • Safety Statements  :36/37/39-45
  • RIDADR  :UN 2811 6.1/PG 2
  • WGK Germany  :3
  • RTECS  :RY7535000
  • HazardClass  :6.1(a)
  • PackingGroup  :II
  • HS Code  :29349990
  • Toxicity :LD50 orl-mus: 10 mg/kg 41KEAL -,108,78
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300
  • Precautionary statements P301+P330+P331+P310
PENITREM A Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: P3053
  • Product name : Penitrem A
  • Purity: ≥95% (HPLC and TLC)
  • Packaging: 1MG
  • Price: ₹30223.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: P3053
  • Product name : Penitrem A
  • Purity: ≥95% (HPLC and TLC)
  • Packaging: 5MG
  • Price: ₹101257.05
  • Updated: 2022/06/14
  • Buy: Buy

PENITREM A Chemical Properties,Usage,Production

  • Description Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+?(BK, KCa1.1) channel (100% block at 10 nM).1?Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2?An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and?in vivo?experiments.3?Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3?May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4
  • Chemical Properties Solid
  • Occurrence A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH.
  • Uses Penitrem A has been used as Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons.
  • Uses Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels.
  • Definition ChEBI: Penitrem A is an organooxygen compound and an organic heterotricyclic compound.
  • Biochem/physiol Actions Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.
  • Safety Profile Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.
  • storage -20°C
  • References References/Citations:
    (1) Knaus et al. (1994), Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels;  Biochemistry, 33 5819
    (2) Breton et al. (1998), Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study; Toxicon., 36 645
    (3) Asano et al. (2012), Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function; J. Pharmacol. Exp.Ther., 342 453
    (4) Lu et al. (2008), Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies; Brain Res. 1207 207
PENITREM A Preparation Products And Raw materials
Raw materials
Preparation Products
PENITREM A Suppliers
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PENITREM A Spectrum
12627-35-9, PENITREM ARelated Search:
  • antibiotic
  • 抑制剂
  • 抗生素
  • 生化试剂
  • 微生物代谢物
  • Voltage-gated Ion Channels
  • Ion Channels
  • Potassium Channel Modulators
  • Monovalent Ion Channels
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • C37H44ClNO6
  • PENITREM A,BLOCKER OF KCA1.1
  • 青霉A
  • 乙腈中青霉震颤素A溶液
  • 青霉震颤素,来自青霉菌
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  • 青霉震颤素(>95%(HPLC),BC)
  • 青霉震颤素 A
  • 12627-35-9
  • Penitrem A, blocker of KCa1.1
  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b...
  • 2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
  • JDUWHZOLEDOQSR-JKPSMKLGSA-N
  • Penitrem A Nsc354845
  • penitrem A from penicillium palitans
  • PENITREM A, PENICILLIUM PAXILLI
  • PENITREM A
  • Penitrem A from Penicillium paxilli
  • TREMORTIN A

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