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C2 CERAMIDE

CAS No.3102-57-6
Chemical Name:C2 CERAMIDE
CBNumber:CB8342539
Molecular Formula:C20H39NO3
Formula Weight:341.53
MOL File:3102-57-6.mol

C2 CERAMIDE Property

Melting point 93-96 °C
Boiling point 477.13°C (rough estimate)
Density 1.0283 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. −20°C
solubility DMSO: soluble
pka 13.50±0.20(Predicted)
form powder
color white
biological source semisynthetic
Stability Moisture Sensitive
FDA UNII 8YTC7R47CW
UNSPSC Code 12352211
NACRES NA.85

Safety

Safety Statements :22-24/25
WGK Germany :3
HS Code :29241990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

C2 CERAMIDE Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: A7191
Product name : N-Acetyl-D-sphingosine
Purity: ≥97% (TLC), powder
Packaging: 1MG
Price: ₹3063.48
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: A7191
Product name : N-Acetyl-D-sphingosine
Purity: ≥97% (TLC), powder
Packaging: 5MG
Price: ₹8952.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 01912
Product name : N-Acetyl-D-sphingosine
Purity: ≥98.0% (TLC)
Packaging: 50MG
Price: ₹10954.9
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 110145
Product name : D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem
Purity: Biologically active, cell-permeable, non-physiological ceramide analog.
Packaging: 5MG
Price: ₹14100
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 01912
Product name : N-Acetyl-D-sphingosine
Purity: ≥98.0% (TLC)
Packaging: 250MG
Price: ₹41438.1
Updated: 2022/06/14
Buy: Buy

C2 CERAMIDE Chemical Properties,Usage,Production

Description C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.
Chemical Properties White Crystalline Solid
Uses A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2
Uses Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases
Definition ChEBI: N-acetylsphingosine is a N-acylsphingosine that has an acetamido group at position 2.
Biological Activity A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .
Biochem/physiol Actions Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.
storage Desiccate at -20°C
References 1) Minano et al. (2008), C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3; J. Neurosci. Res., 86 1734 2) Prinetti et al. (1997), Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells; FEBS Lett., 414 475 3) Zhang et al. (1997), Kinase suppressor of Ras is ceramide-activated protein kinase; Cell, 89 63 4) Matsuzaka et al. (2016) Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation] 5) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]