Description
Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the
de novo synthesis pathway. Certain forms of ceramide have been shown to mediate cellular responses such as apoptosis, growth arrest, and differentiation in certain cell types. C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. It is synthesized
de novo by ceramide synthases 1 and 2.
Chemical Properties
white powder
Uses
C20 Ceramide (cas# 7344-02-7) is a compound useful in organic synthesis.
Definition
ChEBI: N-icosanoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as eicosanoyl. It has a role as a mouse metabolite. It is a N-acylsphingosine and a Cer(d38:1). It is functionally related to an icosanoic acid.
IC 50
Human Endogenous Metabolite
References
[1] COWART L A. Sphingolipids: players in the pathology of metabolic disease.[J]. Trends in Endocrinology and Metabolism, 2009, 20 1: 34-42. DOI:
10.1016/j.tem.2008.09.004[2] YAEL PEWZNER-JUNG Anthony H F Shifra Ben Dor. When do Lasses (longevity assurance genes) become CerS (ceramide synthases): Insights into the regulation of ceramide synthesis.[J]. The Journal of Biological Chemistry, 2006, 281 35: 25001-25005. DOI:
10.1074/jbc.r600010200
