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Azido-PEG4-t-butyl acetate

Azido-PEG4-t-butyl acetate Structure
Azido-PEG4-t-butyl acetate
  • CAS No.864681-04-9
  • Chemical Name:Azido-PEG4-t-butyl acetate
  • CBNumber:CB83062205
  • Molecular Formula:C14H27N3O6
  • Formula Weight:333.38068
  • MOL File:864681-04-9.mol
Azido-PEG4-t-butyl acetate Property
  • solubility Soluble in DMSO, DCM, DMF
  • form Liquid
  • color Colorless to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Azido-PEG4-t-butyl acetate Chemical Properties,Usage,Production

  • Description Azido-PEG4-CH2CO2-t-butyl ester is a PEG reagent containing an azide group and a t-butyl protected carboxyl group. The azide group enables Click Chemistry. The protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. t-butyl ester can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.
  • Uses Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs; Alkyl/ether; Cleavable Linker
  • References [1] Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1.
    [2] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228
Azido-PEG4-t-butyl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG4-t-butyl acetate Suppliers
Global(36)Suppliers
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  • Supplier： Borenpharm Co., Ltd
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Azido-PEG4-t-butyl acetate Spectrum
864681-04-9, Azido-PEG4-t-butyl acetateRelated Search:
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  • Azido-PEG4-t-butyl acetate

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