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LY2334737

LY2334737 Structure
LY2334737
  • CAS No.892128-60-8
  • Chemical Name:LY2334737
  • CBNumber:CB82668271
  • Molecular Formula:C17H25F2N3O5
  • Formula Weight:389.39
  • MOL File:892128-60-8.mol
LY2334737 Property
  • Density 1.41±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • form Powder
  • pka 9.66±0.20(Predicted)
  • color White to off-white
  • FDA UNII YLR364XYSA
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

LY2334737 Chemical Properties,Usage,Production

  • Uses LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects[1][2].
  • Biological Activity ly2334737 is an oral prodrug of gemcitabine, the clinically efficacious anticancer agent [1].ly2334737 has been shown the hydrolytic activity by carboxylesterase 2 (ces2). the michaelis-menten kinetic parameters are exhibited to be : km of 43μm and vmax of 40nmol/min/mg protein. in addition, ly2334737 has been found to be cytotoxic to cells in the ncl-60 panel with the ec50 values of 0.512±0.016μm, 0.402±0.018μm and 0.034±0.002μm for pc-gfp alone, hct-116 mock transfectant and hct-116 ces2 transfectant cell lines, respectively. apart from these, the study result has been noted that parental sk-ov-3 cells were approximately 4-fold more sensitive to ly2334737 cytotoxicity than the sk-ov-3 knockdown with the ec50 values of 1.1μm and 4.5μm, respectively [1].
  • in vivo

    Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days shows greater tumor growth inhibition of CES2 transfectant than the mock transfectant[1].
    Metronomic LY2334737 administration causes increased blood flow in luciferase-tagged LM2-4 tumor xenografts, and this effect, readily measured using contrast micro-ultrasound, coincided with a relative increase in tumor bioluminescence[3].

  • References [1] pratt se1, durland-busbice s, shepard rl, heinz-taheny k, iversen pw, dantzig ah. human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (ly2334737) and confers prodrug sensitivity to cancer cells. clin cancer res. 2013 mar 1;19(5):1159-68.
LY2334737 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2334737 Suppliers
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LY2334737 Spectrum
892128-60-8, LY2334737Related Search:
  • 有机原料
  • 抑制剂
  • 医药研发中间体
  • C17H25F2N3O5
  • 化合物LY2334737,10 MM DMSO 溶液
  • 化合物LY2334737
  • 2'-脱氧-2',2'-二氟-N-(1-氧代-2-丙基戊基)胞苷
  • 892128-60-8
  • LY2334737, 10 mM in DMSO
  • N-(1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide
  • N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-2-propylpentanamide
  • anticancer,HEV,Gemcitabine,HEVs,HRVs,LY 2334737,EV-A71,Rhinovirus,inhibit,Nucleoside Antimetabolite/Analog,Enterovirus,HRV,orally,LY2334737,LY-2334737,antiviral,Inhibitor
  • Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-
  • LY 2334737;LY-2334737;LY2334737
  • 2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine
  • LY2334737

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