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LY2090314

LY2090314 Structure
LY2090314
  • CAS No.603288-22-8
  • Chemical Name:LY2090314
  • CBNumber:CB12628063
  • Molecular Formula:C28H25FN6O3
  • Formula Weight:512.53
  • MOL File:603288-22-8.mol
LY2090314 Property
  • Density 1.55±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility insoluble in H2O; ≥91 mg/mL in DMSO; ≥4.27 mg/mL in EtOH with gentle warming and ultrasonic
  • pka 7.41±0.60(Predicted)
  • form powder
  • color yellow to orange
  • CAS DataBase Reference 603288-22-8
  • FDA UNII 822M3GYM67
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
LY2090314 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1438
  • Product name : LY2090314
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹13011.65
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1438
  • Product name : LY2090314
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹52382.18
  • Updated: 2022/06/14
  • Buy: Buy

LY2090314 Chemical Properties,Usage,Production

  • Uses LY 2090314 is a novel glycogen synthase kinase-3α inhibitor for the treatment of acute myeloid leukemia.
  • Definition ChEBI: LY-2090314 is a member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer. It has a role as an apoptosis inducer, an antineoplastic agent, a Wnt signalling activator and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is an imidazopyridine, a diazepinoindole, a member of monofluorobenzenes, a piperidinecarboxamide, a member of ureas and a member of maleimides.
  • Biological Activity ly2090314 (ly) is a potent inhibitor of glycogen synthase kinase-3 (gsk-3) which plays an important role in various pathways, such as protein synthesis initiation, cell proliferation/differentiation, and apoptosis.
  • Biochem/physiol Actions LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) currently in clinical trials for cancer therapy. LY2090314 has IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
  • in vitro ly2090314 selectively inhibits the activity of gsk-3 by inhibiting atp binding. ly2090314 was reported to be able to stabilize β-catenin. as monotherapy, ly2090314 aslso showed limited efficacy. in solid tumor cancer cell lines, ly3090314 was found to enhance the efficacy of cisplatin and carboplatin [1].
  • in vivo even in mdr1a-, bcrp-, and mrp2-knockout rats, the metabolites of ly2090314 did not appear in systemic circulation, and the urinary excretion was not found to be enhanced, since the hypothesized impaired biliary excretion of metabolites in the absence of these canalicular transporters was not observed. dog metabolite disposition was similar, with the exception of ly2090314 glucuronide. moreover, ly2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts [1]
  • target GSK-3α
  • IC 50 1.5 nm (gsk-3α); 0.9 nm (gsk-3β)
  • References [1] brail lh, et al. j clin oncol, 2011, 29, abstr 3030.
LY2090314 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2090314 Suppliers
Global(113)Suppliers
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LY2090314 Spectrum
603288-22-8, LY2090314Related Search:
  • PI3K
  • mTOR
  • Akt
  • Inhibitors
  • 合成有机化合物配体
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 抑制剂
  • C28H25FN6O3
  • 化合物LY2090314,10 MM DMSO 溶液
  • LY2090314,GSK-3抑制剂
  • GSK-3抑制剂
  • 3-(9-氟-2-(哌啶-1-羰基)-1,2,3,4-四氢-[1,4]二氮杂卓并[6,7,1-HI]吲哚-7-基)-4 -(咪唑并[1,2-A]吡啶-3-基)-1H-吡咯-2,5-二酮
  • GSK-3抑制剂(LY2090314)
  • 603288-22-8
  • LY2090314 USP/EP/BP
  • LY2090314 >=98% (HPLC)
  • 1H-Pyrrole-2,5-dione, 3-[9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-
  • LY 2090314;LY-2090314
  • CS-843
  • LY2090314 100MG
  • LY2090314;LY 2090314;LY-2090314
  • 7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine LY2090314
  • 3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
  • 7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine
  • LY2090314

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