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603288-22-8

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Identification

Name
LY2090314
CAS
603288-22-8
Synonyms
CS-843
LY2090314
LY2090314 100MG
LY2090314 USP/EP/BP
LY 2090314;LY-2090314
LY2090314 >=98% (HPLC)
LY2090314;LY 2090314;LY-2090314
3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-
7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine
7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine LY2090314
Molecular Formula
C28H25FN6O3
MOL File
603288-22-8.mol
Molecular Weight
512.535

Chemical Properties

density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
-20°C
pka
7.41±0.60(Predicted)
form 
powder
color 
yellow to orange
CAS DataBase Reference
603288-22-8

Hazard Information

Uses
LY 2090314 is a novel glycogen synthase kinase-3α inhibitor for the treatment of acute myeloid leukemia.
Biochem/physiol Actions
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) currently in clinical trials for cancer therapy. LY2090314 has IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
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