ChemicalBook CAS DataBase List 154447-36-6

154447-36-6

Name	LY 294002 HYDROCHLORIDE
CAS	154447-36-6
EINECS(EC#)	1312995-182-4
Molecular Formula	C19H18ClNO3
MDL Number	MFCD01530034
Molecular Weight	343.8
MOL File	154447-36-6.mol

Synonyms

SF 1101 LY 294002 NSC 697286 LY294002HCl LY 294002, 99+% LY294002 (HCI Salt) LY 294002 HYDROCHLORIDE 2-Morpholino-8-phenylchroMone 2-Morpholino-8-phenyl-4H-chroMen-4-one 8-Phenyl-2-(morpholin-4-yl)chromen-4-one 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE 2-[4-Morpholinyl]-8-phenyl-1[4H]-benzopyran-4-on 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE LY 294002 8-Phenyl-2-(morpholin-4-yl)chromen-4-one 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE 2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 294002

Chemical Properties

Melting point	183-185℃
Boiling point	494.6±45.0 °C(Predicted)
density	1.266
storage temp.	2-8°C
solubility	DMSO: >5 mg/mL
form	solid
pka	0.55±0.20(Predicted)
color	white to off-white
Water Solubility	Soluble in DMSO at 5mg/ml. Insoluble in water
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChI	InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey	CZQHHVNHHHRRDU-UHFFFAOYSA-N
SMILES	C1(N2CCOCC2)OC2=C(C3=CC=CC=C3)C=CC=C2C(=O)C=1
CAS DataBase Reference	154447-36-6

Safety Data

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H320-H361-H370-H372-H336-H402
Precautionary statements	P501-P273-P260-P270-P202-P201-P271-P264-P280-P337+P313-P305+P351+P338-P308+P311-P301+P312+P330-P304+P340+P312-P403+P233-P405
Safety Statements	24-25 less more
WGK Germany	3
HS Code	29349990

Hazard Information

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC₅₀ of 1.4 μM.

Uses

A potent blocker of PI 3-kinase/Akt signaling.

Uses

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Uses

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Definition

ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.

target

p110α

storage

Store at -20°C

References

1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241

Spectrum Detail

Supplier

Zhengzhou HSH Science & Technology Co., Ltd.

Telephone0371-55932928 18937192232;

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15892/0_EN.htm

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Boyle Chemical Co., Ltd.

Telephone

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Capot Chemical Co., Ltd

Telephone+86 (0) 571 85 58 67 18

Websitehttp://www.capotchem.com/

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070 13770331960

Websitehttp://www.echemlin.cn

Chemsky (shanghai) International Co.,Ltd

Telephone021-50135380

Websitehttp://www.shchemsky.com

Jinan Trio PharmaTech Co., Ltd.

Telephone0531-88811783

Websitehttp://www.trio-pharmatech.com

Shandong Xiya Chemical Co., Ltd

Telephone13355009207 13355009207

Websitehttp://www.xiyashiji.com

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Telephone 13761987713

Websitehttp://www.sunwaypharm.cn

Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

Websitehttp://www.meilunbio.com/

Shanghai Hope Chem Co., Ltd.，

Telephone+21-18501659228 18501659228

Websitehttp://www.hope-chem.com

Artis Chemistry (Shanghai) Co. Ltd.

Telephone86-21-60936353

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15631/0_EN.htm

1of4

Related Products

Send Inquriy