ChemicalBook > CAS DataBase List > 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Structure
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
  • CAS No.28289-54-5
  • Chemical Name:1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
  • CBNumber:CB8254906
  • Molecular Formula:C12H15N
  • Formula Weight:173.25
  • MOL File:28289-54-5.mol
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Property
  • Melting point aprox. 36°C
  • Boiling point 128-132 °C12 mm Hg(lit.)
  • Density 1.001±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Room Temperature
  • solubility Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
  • form Solid
  • pka 8.66±0.40(Predicted)
  • color Pale Yellow to Light Yellow
  • Merck 13,6319
  • Stability Stable. Incompatible with strong oxidizing agents.
  • FDA UNII 9P21XSP91P
Safety
  • Hazard Codes  :T
  • Risk Statements  :25-39/23/24/25
  • Safety Statements  :45
  • RIDADR  :UN 2811 6.1/PG 2
  • WGK Germany  :3
  • RTECS  :UT8358900
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • Hazardous Substances Data :28289-54-5(Hazardous Substances Data)
  • Toxicity :Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H370-H301
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Chemical Properties,Usage,Production

  • Chemical Properties Light Yellow Solid
  • Uses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
  • Definition ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
  • Metabolic pathway N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a rat pheochromocytoma cell line is oxidized to give the N-methyl-4-phenylpyridinium ion.
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Suppliers
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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Spectrum
28289-54-5, 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINERelated Search:
  • Heterocyclic Compounds
  • Neurochemicals
  • 化合物产品
  • 杂环化合物
  • Pyridines
  • Heterocyclic Building Blocks
  • C9 to C46
  • Building Blocks
  • 8289-54-5
  • 哌替啶杂质B
  • 1-甲基-4-苯基-1,2,3,6-四氢吡啶
  • 28289-54-5
  • Naphthoic Acid Impurity 111
  • C12H15N 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 28289-54-5
  • MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
  • N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
  • 1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE
  • 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE
  • 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
  • 1-METHYL-4-PHENYL-PIPERIDINE-3-EN
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin
  • Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base
  • NSC 139654
  • 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride
  • 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine
  • 1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin
  • MPTP

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