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Atrasentan hydrochloride

Atrasentan hydrochloride Structure
Atrasentan hydrochloride
  • CAS No.195733-43-8
  • Chemical Name:Atrasentan hydrochloride
  • CBNumber:CB82128704
  • Molecular Formula:C29H38N2O6.HCl
  • Formula Weight:547.08
  • MOL File:195733-43-8.mol
Atrasentan hydrochloride Property
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Soluble in DMSO
  • form Powder
  • color Off-white to gray
  • InChIKey IJFUJIFSUKPWCZ-FZVADPAUNA-N
  • SMILES C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r|
  • FDA UNII E4G31X93ZA
  • NCI Drug Dictionary atrasentan hydrochloride
  • UNSPSC Code 12352200
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

Atrasentan hydrochloride Chemical Properties,Usage,Production

  • Description Atrasentan Hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
  • Uses Atrasentan belongs to a pyrrolidine and benzodioxole derivative. It is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in the inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Its potential therapeutic uses include the treatment of diabetic nephropathies and as an antineoplastic agent.
  • Biological Activity Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.
  • in vivo

    Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats[1]. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model[2].

Atrasentan hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Atrasentan hydrochloride Spectrum
195733-43-8, Atrasentan hydrochlorideRelated Search:
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  • C29H39ClN2O6
  • C29H38N2O6HCl
  • ATRASENTAN HYDROCHLORIDE (ABT-627 HYDROCHLORIDE)
  • 盐酸阿曲生坦,10 MM DMSO 溶液
  • (2R,3R,4S)-4-(苯并[D][1,3]二氧杂环-5-基)-1-(2-(二丁基氨基)-2-氧乙基)-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐
  • 阿曲生坦盐酸盐
  • 盐酸阿曲生坦
  • (2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐
  • 195733-43-8
  • Atrasentan hydrochloride, 10 mM in DMSO
  • A 147627,A-147627,(+)-A 127722,Atrasentan hydrochloride,Atrasentan,ABT627,ABT-627,Endothelin Receptor,ABT 627,Inhibitor,inhibit,A147627
  • Atrasentan Hydrochloride，ABT627 HCl
  • A-147627 hydrochloride
  • (+)-A 127722 hydrochloride
  • ABT-627 hydrochloride
  • ABT-627; ABT627; ABT 627
  • Atrasentan hydrochloride (ABT-627
  • ABT-627; ABT627; ABT 627; ABBOTT 147627
  • Atrasentan hydrochloride, CID 159595
  • (2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
  • (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
  • 3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-
  • ABT-627
  • ABT627
  • ABT 627
  • Unii-E4G31X93za
  • Atrasentan hydrochloride [usan]
  • Atrasentan HCl
  • Abbott 147627
  • A 147627.1
  • 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-
  • Atrasentan hydrochloride

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