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Arachidonic acid

Description References

Arachidonic acid

CAS No.506-32-1
Chemical Name:Arachidonic acid
CBNumber:CB8112259
Molecular Formula:C20H32O2
Formula Weight:304.47
MOL File:506-32-1.mol

Arachidonic acid Property

Melting point -49 °C (lit.)
Boiling point 169-171 °C/0.15 mmHg (lit.)
Density 0.922 g/mL at 25 °C (lit.)
refractive index n20/D 1.4872(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility ethanol: ≥10 mg/mL
pka 4.75±0.10(Predicted)
form oil
color colorless to light yellow
biological source synthetic
Water Solubility PRACTICALLY INSOLUBLE
Merck 14,765
BRN 1713889
Concentration 1 mCi/ml
Solvent Ethanol under argon
Specific Activity 200-240 Ci/mmol
Stability Light Sensitive, Temperature Sensitive
InChIKey YZXBAPSDXZZRGB-DOFZRALJSA-N
LogP 6.99
CAS DataBase Reference 506-32-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 27YG812J1I
NIST Chemistry Reference Arachidonic acid(506-32-1)
UNSPSC Code 85151701
NACRES NA.77

Safety

Risk Statements :19
Safety Statements :24/25-19
RIDADR :UN1170 - class 3 - PG 2 - Ethanol
WGK Germany :3
RTECS :CE6675000
F :8-10-23
HS Code :29161900
Toxicity :dns-mus:mmr 10 mg/L CRNGDP 5,1123,84

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H319
Precautionary statements P210-P233-P240-P241-P242-P305+P351+P338

Arachidonic acid Price More Price(19)

Brand: Sigma-Aldrich(India)
Product number: A3611
Product name : Arachidonic acid
Purity: from non-animal source, ≥98.5% (GC)
Packaging: 10MG
Price: ₹7837.3
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A3611
Product name : Arachidonic acid
Purity: from non-animal source, ≥98.5% (GC)
Packaging: 100MG
Price: ₹14667.88
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: SAB1412610
Product name : ANTI-FOXC1 antibody produced in mouse
Purity: clone 1E11, purified immunoglobulin, buffered aqueous solution
Packaging: 100μG
Price: ₹52347.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A3611
Product name : Arachidonic acid
Purity: from non-animal source, ≥98.5% (GC)
Packaging: 1G
Price: ₹80137.48
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A-122
Product name : Arachidonic acid
Purity: 1.0?mg/mL in ethanol, certified reference material, Cerilliant?
Packaging: 1ML
Price: ₹20388.9
Updated: 2022/06/14
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Arachidonic acid Chemical Properties,Usage,Production

Description Arachidonic acid belongs to a kind of polyunsaturated omega-6 fatty acid, which is highly biologically relevant. It is abundantly distributed in brain, muscles and liver. It is the precursor for all prostaglandins, thromboxanes, and leukotrienes. Most cellular arachidonic acid is esterified in the membrane phospholipids. It is an important second messenger of cellular signalling participating in the regulation of signaling enzymes including PLC-γ, PLC-δ, and PKC-α, -β, and -γ isoforms. In addition, arachidonic acid acts as key inflammatory intermediate as well as avasodilator. Generally, the body can synthesize the arachidonic acid through linoleic acid. However, upon linoleic acid deficiency, it is necessary to supplement arachidonic acid from the diets. Food sources of arachidonic acid include meat, eggs and some fishes. Alternatively, we can also have arachidonic acid supplements.
References http://www.fitday.com/fitness-articles/nutrition/healthy-eating/what-is-arachidonic-acid.html
https://en.wikipedia.org/wiki/Arachidonic_acid
https://www.caymanchem.com/product/90010
Description Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).
Chemical Properties In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.
Chemical Properties liquid
Uses arachidonic acid is an ingredient with skin-smoothing, emollient, and healing properties. Arachidonic acid is an omega-6 essential fatty acid naturally occurring in the skin and considered critical for appropriate skin metabolism. It is a constituent of vitamin F.
Uses An unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes
Uses Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.
Definition ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
General Description A Certified Spiking Solution^? suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.
Biological Activity Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
Biochem/physiol Actions Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
Safety Profile Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.
Carcinogenicity In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.