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alminoprofen

alminoprofen Structure
alminoprofen
  • CAS No.39718-89-3
  • Chemical Name:alminoprofen
  • CBNumber:CB7885929
  • Molecular Formula:C13H17NO2
  • Formula Weight:219.28
  • MOL File:39718-89-3.mol
alminoprofen Property
  • Melting point 107°
  • Boiling point 360.1°C (rough estimate)
  • Density 1.0697 (rough estimate)
  • refractive index 1.5100 (estimate)
  • storage temp. -20°C Freezer
  • solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 4.86±0.50(Predicted)
  • color Light Brown
  • FDA UNII 0255AHR9GJ
  • ATC code M01AE16
Safety
  • Toxicity :LD50 orally in mice: 2400 mg/kg (Dumaitre)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

alminoprofen Chemical Properties,Usage,Production

  • Description Alminoprofen is an arylpropionic acid analgesic/antiinflammatory agent indicated for the short term management of dental, traumatic and postpartum pain.
  • Originator Labs. Dr. E. Bouchara (France)
  • Uses Alminoprofen is a nonsteroidal antiinflammatory drugs (NSAID) of the phenylpropionic acid class. Alminoprofen maybe a useful therapeutic option in the management of immune dysfunction in rheumatoid ar thritis.
  • Definition ChEBI: A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.
  • Manufacturing Process Methyl 2-(p-aminophenyl)propionate:
    Methyl 2-(p-nitrophenyl)acrylate (52 g) is hydrogenated in ethanol (500 ml) in the presence of 5% palladium-over-charcoal, while maintaining the temperature at +5°C. The theoretical amount of hydrogen is taken up within one hour. After separation of the catalyst and concentration to dryness, the resulting material gives methyl 2-(p-aminophenyl)proprionate which crystallizes: MP: = 40°-43°C.
    Methyl 2-(p-methallylaminophenyl)propionate hydrochloride:
    A mixture of methyl 2-(p-aminophenyl)propionate (44.75 g), methallyl chloride (34 g) and pyridine (30 ml) in isopropanol (400 ml) is boiled during 30 hours. The solvent is removed in vacuo and the residue is taken up into water and ether. After separation, the organic phase is washed repeatedly with water, after which it is dried and concentrated in vacuo. The resulting oil is fractionally distilled in vacuo (0.1 mm Hg; 5 g of oil essentially consisting of methyl 2-(p-aminophenyl)propionate are collected at 115°-120°C; 30 g of oil consisting of a mixture of mono- (80%) and disubstituted (20%) amines is collected at 128°-130°C. This oil is used to prepare the hydrochloride, which is recrystallized from ethyl acetate, to give white crystals (22.7 g) melting at 115°C. Saponification in the cold methanolic hydroxide gives the desired 2-(4- (methallylamino)phenyl)propionic acid (alminoprofen). MP: 120°C.
  • brand name MINALFENE
  • Therapeutic Function Analgesic, Antiinflammatory
alminoprofen Preparation Products And Raw materials
Raw materials
Preparation Products
alminoprofen Suppliers
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alminoprofen Spectrum
39718-89-3, alminoprofenRelated Search:
  • 抑制剂
  • 药靶配体
  • 化合物 ALMINOPROFEN
  • EB382|||EB 382|||EB-382
  • 2-(4-((2-甲基丙烯基)氨基)苯基)丙酸
  • 化合物 T23706
  • 2-(4-((2-甲基烯丙基)氨基)苯基)丙酸
  • 阿米洛芬
  • 阿明洛芬
  • 胺普芬
  • 39718-89-3
  • Alminoprofen CAS NO.39718-89-3
  • AlminoprofenQ: What is Alminoprofen Q: What is the CAS Number of Alminoprofen Q: What is the storage condition of Alminoprofen Q: What are the applications of Alminoprofen
  • alminoprofen USP/EP/BP
  • Benzeneacetic acid, α-methyl-4-[(2-methyl-2-propen-1-yl)amino]-
  • 2-(4-((2-Methylallyl)aMino)phenyl)propanoic acid
  • α-Methyl-4-[(2-Methyl-2-propen-1-yl)aMino]benzeneacetic Acid
  • rac AlMinoprofen
  • Alminoprofeno
  • Alminoprofene [inn-french]
  • Alminoprofene
  • Acide (methallylamino-4 phenyl)-2 propionique [french]
  • Acide (methallylamino-4 phenyl)-2 propionique
  • 4-((2-Methylallyl)amino)hydratropasaeure
  • 2-(4-((2-Methylallyl)amino)phenyl)propansaeure
  • α-Methyl-4-[(2-methyl-2-propenyl)amino]benzeneacetic acid
  • Minalfen
  • 4-[(2-Methyl-2-propenyl)amino]hydratropic acid
  • 2-[4-(Methallylamino)phenyl]propanoic acid
  • Minalfene
  • EB 382
  • ALMINOPROFEN(FORR&DONLY)
  • alminoprofen

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