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Rhodamine B

CAS No.81-88-9
Chemical Name:Rhodamine B
CBNumber:CB7485569
Molecular Formula:C28H31ClN2O3
Formula Weight:479.01
MOL File:81-88-9.mol

Rhodamine B Property

Melting point 210-211 (dec.)(lit.)
Density 0.79 g/mL at 20 °C
bulk density 250kg/m3
refractive index 1.6500 (estimate)
Flash point 12 °C
storage temp. room temp
solubility H2O: soluble1mg/mL
Colour Index 45170
form Solid
color Green
PH 3-4 (10g/l, H2O, 20℃)
Water Solubility SOLUBLE
ε(extinction coefficient) 104500-115800 at 542-554nm in methanol
Merck 14,8183
BRN 4119648
Stability Stable. Incompatible with strong oxidizing agents.
LogP 1.9-2
CAS DataBase Reference 81-88-9(CAS DataBase Reference)
EWG's Food Scores 3-6
FDA UNII K7G5SCF8IL
NIST Chemistry Reference Rhodamine b(81-88-9)
Proposition 65 List D&C Red No. 19
IARC 3 (Vol. 16, Sup 7) 1987
EPA Substance Registry System Rhodamine B (81-88-9)
UNSPSC Code 85151701
NACRES NA.47

Safety

Hazard Codes :Xn,Xi,F
Risk Statements :22-41-68-67-36-11-40-20/21/22-52/53
Safety Statements :7-16-24/25-26-36/37/39-39-36-22
WGK Germany :3
RTECS :BP3675000
TSCA :Yes
HS Code :32041300
Hazardous Substances Data :81-88-9(Hazardous Substances Data)
Toxicity :LD50 i.v. in rats: 89.5 mg/kg (Webb)

NFPA 704:

	1
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H319-H336
Precautionary statements P210-P305+P351+P338

Rhodamine B Price More Price(17)

Brand: Sigma-Aldrich(India)
Product number: R6626
Product name : Rhodamine B
Purity: ≥95% (HPLC)
Packaging: 25G
Price: ₹3090
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: R6626
Product name : Rhodamine B
Purity: ≥95% (HPLC)
Packaging: 100G
Price: ₹3220
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: R6626
Product name : Rhodamine B
Purity: ≥95% (HPLC)
Packaging: 500G
Price: ₹12830
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Brand: Sigma-Aldrich(India)
Product number: 83689
Product name : Rhodamine B
Purity: for fluorescence
Packaging: 1G
Price: ₹6648.9
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 79754
Product name : Rhodamine B
Purity: analytical standard
Packaging: 25MG
Price: ₹13453.2
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Rhodamine B Chemical Properties,Usage,Production

Description C.I. Food red 15 is a green crystalline or redviolet powdered solid. Molecular weight =479.1. HazardIdentification (based on NFPA-704 M Rating System):Health 1, Flammability 1, Reactivity 0. Highly soluble inwater.
Chemical Properties red/brown or green crystals
Chemical Properties C.I. Food red 15 is a green crystalline or redviolet powdered solid
Uses A useful fluorochrome for histology, FRET and mitochondrial probe.
Uses Rhodamine B is used in biological studies for an anti-reactive oxygen species/hepatic fibrosis drug delivery system based on salvianolic acid B loaded mesoporous silica nanoparticles. Dyes and metabolites, Environmental Testing.
Uses As a dye, especially for paper; as a reagent for antimony, bismuth, cobalt, niobium, gold, manganese, mercury, molybdenum, tantalum, thallium, tungsten; as biological stain. Provisionally listed for use in drugs and cosmetics.
Definition ChEBI: An organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome.
General Description Green crystals or reddish-violet powder. Used as a dye, especially for paper, as a metal chelating reagent, and in drugs and cosmetics.
Air & Water Reactions Very soluble in water. Solution is bluish-red. Dilute solutions are strongly fluorescent.
Reactivity Profile Acidic organic/inorganic salts, such as Rhodamine B, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Hazard Questionable carcinogen.
Potential Exposure It is used as a color additive in drugs, foods, cosmetics, and fabric dyes. It is also used as a tracing agent in water pollution studies. May be used as an agricultural chemical
First aid If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
storage Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with C.I. Foodred 15 you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers and reducing agents.Where possible, automatically pump liquid from drums orother storage containers to process containers.
Shipping UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods Major impurities are partially dealkylated compounds not removed by recrystallisation.Purify the dye by chromatography, using ethyl acetate/isopropanol/ammonia (conc)(9:7:4, RF 0.75 on Kieselgel G). It has also been crystallised from a concentrated solution in MeOH by slow addition of dry diethyl ether; or from EtOH containing a drop of conc HCl by slow addition of ten volumes of dry diethyl ether. The solid is washed with ether and air dried. The dried material has also been extracted with *benzene to remove oil-soluble material prior to recrystallisation. Store it in the dark. [Beilstein 18 II 486, 18 III/IV 8246, 19/8 V 669.]

Properties and Applications

TEST ITEMS	SPECIFICATION
APPEARANCE	GREEN GLITTERY CRYSTAL
SHADE (COMPARE TO STANDARD)	CLOSE
WATER SOLUBILITY (60°C)	8 g/L min
WATER INSOLUBLE	0.5% max
TINTING STRENGTH	500-505 %

Incompatibilities Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, strong reducing agents