81-88-9

Green crystals or reddish-violet powder. Used as a dye, especially for paper, as a metal chelating reagent, and in drugs and cosmetics.

Acidic organic/inorganic salts, such as C.I. FOOD RED 15(81-88-9), are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Very soluble in water. Solution is bluish-red. Dilute solutions are strongly fluorescent.

Questionable carcinogen.

It is used as a color additive in drugs, foods, cosmetics, and fabric dyes. It is also used as a tracing agent in water pollution studies. May be used as an agricultural chemical

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek Medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a Medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, strong reducing agents

C.I. Food red 15 is a green crystalline or redviolet powdered solid. Molecular weight =479.1. HazardIdentification (based on NFPA-704 M Rating System):Health 1, Flammability 1, Reactivity 0. Highly soluble inwater.

C.I. Food red 15 is a green crystalline or redviolet powdered solid

red/brown or green crystals

A useful fluorochrome for histology, FRET and mitochondrial probe.

As a dye, especially for paper; as a reagent for antimony, bismuth, cobalt, niobium, gold, manganese, mercury, molybdenum, tantalum, thallium, tungsten; as biological stain. Provisionally listed for use in drugs and cosmetics.

Rhodamine B is used in biological studies for an anti-reactive oxygen species/hepatic fibrosis drug delivery system based on salvianolic acid B loaded mesoporous silica nanoparticles. Dyes and metabolites, Environmental Testing.

ChEBI: An organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome.

(1) Phthalic anhydride (15.7 g) and 3-(N,N-dimethylamino) phenol (18.0 g) were added to 1,2-dichlorobenzene (57.0 g). The resulting mixture was stirred at 175 °C for 1 hour and then 3-(N,N-diethylamino) phenol (12.1 g) was added in three batches. After the addition was completed, the reaction mixture was continued to be stirred at 175 °C for 12 hours. After completion of the reaction, the mixture was cooled to below 25°C. Subsequently, 3% aqueous sodium hydroxide solution (100 g) was added and stirred for 30 minutes. After separating the organic layer, 4.5% sulfuric acid (330 g) was added and stirred for 30 minutes. After separation of the aqueous layer, 35% hydrochloric acid (30 g) and sodium chloride (15 g) were added and the mixture was stirred at 80 °C for 1 hour. After cooling to room temperature, the resulting crystals were filtered, washed with 2% hydrochloric acid (300 g) and dried at 80 °C to give the compound of [chemical formula Di] (35 g).

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with C.I. Foodred 15 you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers and reducing agents.Where possible, automatically pump liquid from drums orother storage containers to process containers.

TEST ITEMS	SPECIFICATION
APPEARANCE	GREEN GLITTERY CRYSTAL
SHADE (COMPARE TO STANDARD)	CLOSE
WATER SOLUBILITY (60°C)	8 g/L min
WATER INSOLUBLE	0.5% max
TINTING STRENGTH	500-505 %

Major impurities are partially dealkylated compounds not removed by recrystallisation.Purify the dye by chromatography, using ethyl acetate/isopropanol/ammonia (conc)(9:7:4, RF 0.75 on Kieselgel G). It has also been crystallised from a concentrated solution in MeOH by slow addition of dry diethyl ether; or from EtOH containing a drop of conc HCl by slow addition of ten volumes of dry diethyl ether. The solid is washed with ether and air dried. The dried material has also been extracted with *benzene to remove oil-soluble material prior to recrystallisation. Store it in the dark. [Beilstein 18 II 486, 18 III/IV 8246, 19/8 V 669.]

[1] Patent: US2015/322265, 2015, A1. Location in patent: Paragraph 0064